The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition.

By D. Goetz, M. Holmes, N. Borregaard, Martin E. Bluhm, K. Raymond, R. Strong. Molecules and Cells, 2002

1,331 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Nephrology

View Paper: https://www.semanticscholar.org/paper/1474e009bb0e92861875738acfd023c94f6cf57c

How researchers see this paper

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In Immunology

1. Shizuo Akira
2. G. Núñez
3. Shintaro Sato
4. N. Inohara
5. R. Medzhitov
6. Alan Aderem
7. P. Devarajan
8. B. Barres

In Molecular Biology

1. G. Núñez
2. M. Zeng
3. B. Barres
4. Shizuo Akira
5. Eric P. Skaar
6. N. Inohara
7. Paul Tempst
8. H. Erdjument‐Bromage

In Nephrology

1. G. Núñez
2. P. Devarajan
3. Shizuo Akira

Citations in the corpus

• An iron delivery pathway mediated by a lipocalin. (2002, methodology): “Dimeric and monomeric Ngal were produced by C87S mutagenesis (50 g/ml; Goetz et al., 2002).”
• The Battle for Iron between Bacterial Pathogens and Their Vertebrate Hosts (2010, background): “A second layer of nutritional immunity employed by vertebrates is to combat siderophore-mediated iron acquisition through the production of siderocalin [18].”
• Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron (2004, background): “We recently demonstrated that enterochelin, a bacterial catecholate siderophore, binds to the host protein lipocalin 2 (ref”
• Mechanisms of inflammation-driven bacterial dysbiosis in the gut (2016, positive): “Lipocalin-2, for instance, is produced by both mucosal epithelial cells and infiltrating neutrophils in response to inflammation, as a strategy to prevent bacterial iron acquisition by binding and sequestering the siderophore enterobactin.(83,84) A recent study showed that enterobactin, a catecholat”
• Origins and virulence mechanisms of uropathogenic Escherichia coli. (2008, background): “Goetz and colleagues found that lipocalin 2 functions as a bacteriostatic agent by specifically binding and sequestering enterobactin (Goetz et al., 2002).”
• The Genus Alistipes: Gut Bacteria With Emerging Implications to Inflammation, Cancer, and Mental Health (2020, background): “Lipocalin 2 (LCN 2), an anti-microbial protein that binds to siderophores ultimately reduces iron availability (73).”