The Battle for Iron between Bacterial Pathogens and Their Vertebrate Hosts

By Eric P. Skaar. PLoS Pathogens, 2010

768 citations recorded by the source corpus.

Iron is a vital nutrient for virtually all forms of life. The requirement for iron is based on its role in cellular processes ranging from energy generation and DNA replication to oxygen transport and protection against oxidative stress. Bacterial pathogens are not exempt from this iron requirement, as these organisms must acquire iron within their vertebrate hosts in order to replicate and cause disease.

Subfields: Endocrinology, Hematology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/68c253bdd9a1ff3a6c0ef4878f9df162c70fcc35

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology

1. G. Núñez
2. N. Inohara
3. W. J. Kenyon
4. M. Spector
5. M. Zeng

In Hematology

1. G. Núñez
2. N. Inohara
3. W. J. Kenyon
4. M. Spector
5. M. Zeng

In Nutrition and Dietetics

1. G. Núñez
2. N. Inohara
3. W. J. Kenyon
4. M. Spector
5. M. Zeng

Citations in the corpus

• Mechanisms of inflammation-driven bacterial dysbiosis in the gut (2016, positive): “To circumvent host iron restriction, many bacteria produce and release iron-chelating molecules, termed siderophores, with high affinities for Fe3þ to compete against hostmediated sequestration of iron via heme acquisition and transferrin/lactoferrin receptors.(79,80) Enterobacteriaceae are equipped”
• Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease (2017, background): “These uptake systems include release of iron -chelating siderophores, heme acquisition systems and transferrin/lactoferrin receptors (190).”
• Resistance and survival strategies of Salmonella enterica to environmental stresses (2012, background): “Iron serves as an important cofactor for proteins involved in a number of physiological processes ranging fromcellular respiration, to DNA replication and repair, to the regulation of gene expression (Benjamin et al., 2010; Skaar, 2010).”
• UroPathogenic Escherichia coli (UPEC) Infections: Virulence Factors, Bladder Responses, Antibiotic, and Non-antibiotic Antimicrobial Strategies (2017, background): “Iron acquisition is a critical requirement for UPEC survival in an environment that is iron-limited as the urinary tract (Skaar, 2010).”