Loss of autophagy in the central nervous system causes neurodegeneration in mice

By M. Komatsu, S. Waguri, T. Chiba, S. Murata, Jun-ichi Iwata, I. Tanida, T. Ueno, Masato Koike, Y. Uchiyama, E. Kominami and 1 more. Nature, 2006

3,615 citations recorded by the source corpus.

Subfields: Epidemiology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/13537227185f7a040d7f40ddafdbf73807a689b9

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Citations in the corpus

Autophagy and aging. (2011, background): “CR and resveratrol induce Enhanced inflammation, steatohepatitis, enhanced frequency of hepatocellular carcinomas, lung adenocarcinomas, and lymphomas in aging mice; enhanced accumulation of intraneuronal amyloid ß upon transgenic expression of human amyloid precursor protein Aging-related malignanc”
Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons (2012, background): “Neuronspecific disruption of autophagy results in neurodegeneration (Hara et al., 2006; Komatsu et al., 2006).”
Mitophagy: mechanisms, pathophysiological roles, and analysis (2012, background): “Keywords: autophagy; mitophagy; Nix; Parkin.”
p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation (2016, positive): “ila to mice suggest that the inactivation of autophagy by pharmacological or genetic inhibition causes the accumulation of ubiquitinated proteins in the brain [48, 49], skeletal muscle, cardiac muscle, pancreatic β-cells, podocytes and hepatocytes.”
Cardiac autophagy is a maladaptive response to hemodynamic stress. (2007, background): “In other settings, however, dysregulated autophagy may contribute to the pathogenesis of disease (4), including neuro-degenerative disorders (8–10), skeletal myopathy, cancer (11, 12), and infectious diseases (13).”
FoxO3 controls autophagy in skeletal muscle in vivo. (2007, background): “This interpretation is consistent with the finding that proteasome function is not affected by loss of autophagy in the brain (Komatsu et al., 2006).”
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities. (2017, positive): “…further delineate the function of autophagy in different neuronal types, targeted knockouts of Atg5 and Atg7 in Purkinje neurons of the cerebellum (Komatsu et al., 2006; Nishiyama et al., 2007), Atg7 in Agouti Related Peptide (AgRP) neurons of the hypothalamus (Kaushik et al., 2011), as well as…”