hDOT1L links histone methylation to leukemogenesis.

By Y. Okada, Qin Feng, Yihui Lin, Q. Jiang, Yaqiang Li, V. M. Coffield, L. Su, Guoliang Xu, Yi Zhang. Cell, 2005

845 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/132e7e362f3597aab6428b6e819e44a7edaa7539

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Citations in the corpus

JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. (2006, background): “It has become clear that histone methylation is an important part of this histone modiﬁcation repertoire and functions in heterochromatin formation, X chromosome inactivation, and transcriptional regulation (Margueron et al., 2005; Martin and Zhang, 2005).”
Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact (2012, neutral): “The second class of KMTs is represented solely by KMT4 (also known as Dot1p in yeast and Dot1L in human), which does not have a SET domain (Okada et al., 2005; van Leeuwen et al., 2002).”
Histone Marks in the 'Driver's Seat': Functional Roles in Steering the Transcription Cycle. (2017, background): “This mark was first demonstrated to be associated with active chromatin on select genes [77,78], and both H3K79me2 and H3K79me3 are associated with active transcription Gates et al.”
Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor (2011, positive): “…including theMV4-11 cell line (Chang et al., 2010; Guenther et al., 2008; Jo et al., 2011; Krivtsov et al., 2008; Lin et al., 2010; Milne et al., 2005; Monroe et al., 2010; Mueller et al., 2009; Nguyen et al., 2011; Okada et al., 2005; Thiel et al., 2010; Yo- koyama et al., 2010).”
High-resolution profiling of histone methylations in the human genome. (2007, background): “H3K79me3 does not show a correlation with either active or silent genes in yeast (Pokholok et al., 2005), while H3K79me2 was linked to active transcription in Drosophila (Schubeler et al., 2004) and in humans (Okada et al., 2005).”
The diverse functions of histone lysine methylation (2005, background): “While many histone lysine methyltransferases are linked to cancer, EZH2 and hDOT1L are probably the best examples 112,121 .”
Covalent histone modifications: miswritten, misinterpreted, and miserased in human cancers (2010, background): “first reported that the AF10 portion of MLL–AF10 (Ref”
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. (2006, background): “Aberrant histone methylation has been linked to a number of human diseases such as cancer (Fraga et al., 2005; Hake et al., 2004; Schneider et al., 2002; Varambally et al., 2002; Hess, 2004a; Okada et al., 2005).”