A model for human ventricular tissue.

By 3584 CH Padualaan 8. American Journal of Physiology. Heart and Circulatory Physiology, 2004

1,390 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/12febaf4e09ff27ec0e6ddd09714275cd823aed5

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In Cardiology and Cardiovascular Medicine

In Molecular Biology

Citations in the corpus

Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity (2017, methodology): “In that study, variability was taken into account by using diﬀerent AP models (Ten Tusscher, 2003; Ten Tusscher and Panﬁlov, 2006; O’Hara et al., 2011) and diﬀerent cell types (endo-, epi-, and mid-myocardium).”
Evaluation of a Rapid Anisotropic Model for ECG Simulation (2017, background): “The ionic model, only present in the R-D model, was TNNP (ten Tusscher et al., 2004).”
Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation (2011, neutral): “The TP model[81] and updated”
Models of cardiac tissue electrophysiology: progress, challenges and open questions. (2011, methodology): “Since about 90% of the ventricular cell membrane is located within clefts and the t-tubule system, a specific membrane capacitance of 1 mF cm 2 is justified (Noble, 1979) although some tissue models have used a higher value of 2 mF cm 2 (TenTusscher et al., 2004).”
Alternans and spiral breakup in a human ventricular tissue model. (2006, background): “In experiments it was also found that factors other than mere APD restitution slope are important in determining whether alternans or fibrillation occurs.”
A computational model of the human left-ventricular epicardial myocyte. (2004, background): “Ten Tusscher et al. (2003) subsequently presented a human myocyte model in which properties of membrane currents are based on more recent whole-cell current data measured in isolated human ventricular myocytes.”
hERG K(+) channels: structure, function, and clinical significance. (2012, methodology): “The authors note that their implementation is dramatically different from previous uses, with shifts of up to 60 mV in its steady-state gating characteristics (620).”
A Novel Computational Model of the Human Ventricular Action Potential and Ca Transient (2009, methodology): “Among these, the Panfilov group has comprehensively modeled the individual currents generating an AP, with APD and conduction velocity restitution properties in agreement with experimental measurements (TNNP04 and TP06) [8,10].”