Evaluation of a Rapid Anisotropic Model for ECG Simulation
By Simone Pezzuto, Peter Kal'avský, Mark Potse, F. Prinzen, A. Auricchio, R. Krause. 2017
52 citations recorded by the source corpus.
State-of-the-art cardiac electrophysiology models that are able to deliver physiologically motivated activation maps and electrocardiograms (ECGs) can only be solved on high-performance computing architectures. This makes it nearly impossible to adopt such models in clinical practice. ECG imaging tools typically rely on simplified models, but these neglect the anisotropic electric conductivity of the tissue in the forward problem. Moreover, their results are often confined to the heart-torso interface. We propose a forward model that fully accounts for the anisotropic tissue conductivity and produces the standard 12-lead ECG in a few seconds. The activation sequence is approximated with an eikonal model in the 3d myocardium, while the ECG is computed with the lead-field approach. Both solvers were implemented on graphics processing units and massively parallelized. We studied the numerical convergence and scalability of the approach. We also compared the method to the bidomain model in terms of ECGs and activation maps, using a simplified but physiologically motivated geometry and 6 patient-specific anatomies. The proposed methods provided a good approximation of activation maps and ECGs computed with a bidomain model, in only a few seconds. Both solvers scaled very well to high-end hardware. These methods are suitable for use in ECG imaging methods, and may soon become fast enough for use in interactive simulation tools.
Subfields: Cardiology and Cardiovascular Medicine, Radiology, Nuclear Medicine and Imaging
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Citations in the corpus
- Physics-Informed Neural Networks for Cardiac Activation Mapping (2020, background): “The electrical activation map of the heart can be related to a traveling wave, where the wavefront represents the location of cells that are depolarizing [19].”
- Fast uncertainty quantification of activation sequences in patient‐specific cardiac electrophysiology meeting clinical time constraints (2018, unknown): “ψ(x) = min y∈U {δ(x, y) + ψ(y)} , for allx ∈ ΩandU = ∂B(x, h) ⊂ Ω, (20)”