A computational model of the human left-ventricular epicardial myocyte.

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Solvers for the Cardiac Bidomain Equations (2007, background): “…variable model in 1952(Hodgkin and Huxley, 1952), newer models have upwards of 20 state variables(Priebe and Beuckelmann, 1998; Hund and Rudy, 2004; Iyer et al., 2004) which use fluid compartment models to keep track of intracellular ion concentrations in addition to ion transport across the…”
hERG K(+) channels: structure, function, and clinical significance. (2012, background): “1 channel block (approximated by reducing IKr conductance) in models of human ventricular cells have recapitulated some of the pro-arrhythmogenic biomarkers that are associated with druginduced prolongation of the QT interval (219, 286, 454, 621).”
Alternans and spiral breakup in a human ventricular tissue model. (2006, unknown): “Similar approaches have been taken in many recent models (19, 20, 54).”
Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation (2011, methodology): “However, findings from the Iyer human model[34] differ, at least in part, regarding this mechanism.”