hERG K(+) channels: structure, function, and clinical significance.

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Tuning hERG out: Antitarget QSAR Models for Drug Development (2014, background): “These channels are expressed in a wide array of tissues, but their physiological function is best characterized in cardiac cells, where they play a critical role in the repolarization of the cardiac action potential [1].”
Predicting drug metabolism: experiment and/or computation? (2015, background): “A relevant example is cardiotoxicity caused by several (often but not exclusively) lipophilic drugs belonging to various pharmacological classes by blocking the human ERG potassium channel at therapeutic doses 115 .”
Compilation and physicochemical classification analysis of a diverse hERG inhibition database (2016, neutral): “binding at position 652, therefore its role was attributed to p-cation interactions with basic nitrogen of the ligand, or p-stacking with its aromatic rings [1, 2, 8].”