The weight of leptin in immunity

By A. Cava, G. Matarese. Nature reviews. Immunology, 2004

927 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/12efb93d221744befb7d75b21fe8f1a8ece0045b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. Herbert Tilg
2. Jan Born
3. A. Moschen

In Epidemiology

1. Herbert Tilg
2. A. Moschen
3. Ruth E. Ley
4. A. Kaser
5. Jeffrey I. Gordon
6. Luciana Besedovsky
7. T. Lange

In Nutrition and Dietetics

1. Ruth E. Ley
2. Jeffrey I. Gordon
3. Herbert Tilg
4. A. Moschen

Citations in the corpus

• Inflammatory Mechanisms in the Regulation of Insulin Resistance (2008, background): “M O L M E D 1 4 ( 3 - 4 ) 2 2 2 - 2 3 1 , M A R C H - A P R I L 2 0 0 8 | T I L G A N D M O S C H E N | 2 2 5 both a long, full-length form (OBRb) and a short, truncated form, led to the hope that researchers had identified a highly effective molecule and/or pathway that could be targeted in the tre”
• Adipocytokines in Obesity and Metabolic Disease (2014, neutral): “Conversely, leptin increases thymic secretion of acute- phase reactants and TNFa and promotes T helper 1 cell differentiation (La Cava & Matarese 2004).”
• Human nutrition, the gut microbiome, and immune system: envisioning the future (2011, background): “Leptin regulates appetite and is a pleiotropic cytokine, maintaining thymic output and cellularity and promoting the dominance of T helper 1 (T H 1) cells over T H 2 cell”
• Visfatin, an Adipocytokine with Proinflammatory and Immunomodulating Properties1 (2007, background): “Leptin, the other major product of adipocytes, also affects many aspects of inflammation and immunity (23).”
• Leptin and Obesity: Role and Clinical Implication (2021, background): “The effects of leptin are manifold; it stimulates the expression of IL-1Ra, a cluster of differentiation (CD) 25, CD39, CD69, and CD71 (76), and the production of proinflammatory cytokines TNF-a and IL-6 (77) in macrophages.”
• Adipocytokines: mediators linking adipose tissue, inflammation and immunity (2006, background): “Adiponectin , leptin , resistin and visfatin are adipocytokines and are thought to provide an important link between obesity, insulin resistance and related inflammatory disorder”
• Sleep and immune function (2011, background): “Whereas the boost in stimulated cytokine production during the rest period can be explained by the above-mentioned shift towards increased release of hormones with proinflammatory actions [7, 39, 41, 57, 58, 65, 70, 93], the question arises why spontaneous cytokine release shows a parallel rhythm.”
• Host genetic variation impacts microbiome composition across human body sites (2015, background): “Leptin has several important roles in immunity, including activation of monocytes, neutrophils, and macrophages, and modulation of inflammation [39].”
• Impact of Obesity and Metabolic Syndrome on Immunity. (2016, background): “Leptin is among the most well characterized of these adipokines and plays important roles in metabolism and immunity (123).”