Tolerogenic dendritic cells.

By R. Steinman, D. Hawiger, Michel C. Nussenzweig. Annual Review of Immunology, 2003

1,652 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/12dfed9e529acb43d4c15cc7d145e7093c7a7153

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In Immunology

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Citations in the corpus

• IMMUNE TOLERANCE INDUCTION BY APOPTOTIC CELLS REQUIRES CASPASE-DEPENDENT OXIDATION OF HMGB1 (2008, background): “Antigens associated with engulfed dying cells are channeled into the exogenous pathway of class I major histocompatibility complex (MHC) presentation for stimulation of CD8+ T cells (Blachere et al., 2005; Dudziak et al., 2007; Ferguson et al., 2002; Steinman et al., 2003).”
• Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells (2008, background): “The role of LCs in the induction of tolerance to peripheral antigens in the steady state is starting to be unravele”
• The polarization of immune cells in the tumour environment by TGFβ (2010, background): “Non-activated or immature DCs can still present antigen but, in the absence of proper co-stimulation, this results in T cell toleranc”
• Shaping and reshaping CD8+ T-cell memory (2008, background): “As a consequence of infection or immunization, DCs acquire foreign antigens and differentiate into mature antigen-presenting cells (APCs) that express co-stimulatory molecules, produce cytokines and migrate to secondary lymphoid organs to initiate responses from the rare, pathogen-specific CD8 + T ”
• Dendritic cells in a mature age (2006, background): “DC maturation and peripheral tolerance There is now ample experimental evidence that DCs in the steady state — that is, in the absence of deliberate exposure to maturation signals — can tolerize peripheral CD4 + and CD8 + T cells by inducing deletion, anergy or regulation, depending on the mode”
• Type I interferon is selectively required by dendritic cells for immune rejection of tumors (2011, positive): “The importance of such stimuli is clear because cross­ presentation without activation can lead to tolerance rather than immunity (Steinman et al., 2003; Melief, 2008).”