Arabidopsis ARGONAUTE1 is an RNA Slicer that selectively recruits microRNAs and short interfering RNAs.

By N. Baumberger, David C. Baulcombe. Proceedings of the National Academy of Sciences of the United States of America, 2005

1,117 citations recorded by the source corpus.

Subfields: Plant Science

View Paper: https://www.semanticscholar.org/paper/12bae99f18f80aba42411ff40a70f6d3a42ee76a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Plant Science

Citations in the corpus

Temporal regulation of shoot development in Arabidopsis thaliana by miR156 and its target SPL3 (2006, background): “ZIP/AGO7 encodes one of 10 Argonaute-like proteins in Arabidopsis, at least one of which (AGO1) mediates miRNA- and ta-siRNA-directed RNA cleavage (Baumberger and Baulcombe, 2005; Qi et al., 2005).”
Post-transcriptional small RNA pathways in plants: mechanisms and regulations. (2006, background): “2005) and guide sequencespecific ARGONAUTE1 (AGO1)-catalyzed mRNA cleavage (Morel et al. 2002; Baumberger and Baulcombe 2005; Qi et al. 2005).”
Gene silencing in plants using artificial microRNAs and other small RNAs. (2008, background): “In Arabidopsis, ARGONAUTE1 (AGO1) directs both miRNA- and siRNA-mediated target cleavage without requiring further protein partners (Baumberger and Baulcombe, 2005).”
Evolution and Functional Diversification of MIRNA Genes (2011, background): “The majority of plant miRNAs associate with AGO1 and bind target transcripts at highly complementary sites, usually one per target (Baumberger and Baulcombe, 2005; Mi et al., 2008; Cuperus et al., 2010a).”
Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. (2008, background): “As the founding member of Argonaute family (Bohmert et al., 1998, AGO1 predominates in the miRNA pathway and is also involved in posttranscriptional gene silencing (PTGS) of transgenes (Baumberger and Baulcombe, 2005; Morel et al., 2002; Qi et al., 2005; Vaucheret et al., 2004).”
Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense. (2006, background): “CMV 2b interferes with miRNA pathways in Arabidopsis CMV 2b was among the first suppressors identified that could abrogate PTGS of sense-GFP transgene expression in N. benthamiana (Beclin et al. 1998; Brigneti et al. 1998).”
MicroRNAS and their regulatory roles in plants. (2006, background): “Moreover, although the biological and biochemical roles of Arabidopsis AGO2 are not known, it is intriguing that AGO2 mRNA is targeted by miR403 (3). miRNA targeting of DCL1 and AGO1 suggests a feedback mechanism whereby miRNAs negatively regulate their own activity.”
Plant microRNAs: new players in functional genomics (2013, positive): “Following the detachment of miRNA duplex in the cytoplasm, one strand (mostly miRNA strand) of the miRNA/miRNA* duplex is selectively incorporated with RNA-induced silencing complex (RISC) containing an Argonaute (AGO) family protein, while the other strand (the miRNAs*) is degraded (Baumberger and ”
Small RNAs and Their Roles in Plant Development (2009, background): “The cleavage is mediated by the endonuclease activity of AGO1 (Baumberger & Baulcombe 2005, Qi et al. 2005).”
The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster. (2006, background): “Of the 10 Argonaute family members in Arabidopsis, only Argonaute 1 has thus far been demonstrated to contain Slicer activity, but it does not appear to associate with viral siRNA (Baumberger and Baulcombe 2005).”
RNAi-mediated chromatin silencing in fission yeast. (2008, background): “In other organisms, the effector complex RISC containing Argonaute and guide siRNAs is known to target homologous mRNAs and inhibit their expression by either binding the mature mRNA and blocking their translation or by inducing their degradation by virtue of the ‘slicer’ endonuclease activity inher”
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. (2005, background): “Conversely, Arabidopsis thaliana Argonaute1, a miRNA-guided plant Argonaute protein with a functional endonuclease domain ( Baumberger and Baulcombe, 2005; Qi et al., 2005), might be loaded by a passenger-strand cleavage-assisted pathway.”
Functions of microRNAs and related small RNAs in plants (2006, background): “thaliana , where the mature single-stranded miRNA guides the RNA slicing activity of AGO1 to partially complementary mRNA”
A diverse and evolutionarily fluid set of microRNAs in Arabidopsis thaliana. (2006, background): “The miRNA strand preferentially incorporates into a silencing complex that has at its core the ARGONAUTE1 (AGO1) protein (Vaucheret et al. 2004; Baumberger and Baulcombe 2005; Qi et al. 2005).”