The effect of infections on susceptibility to autoimmune and allergic diseases.

By J. Bach. New England Journal of Medicine, 2002

2,688 citations recorded by the source corpus.

Subfields: Dermatology, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/1284016a89ce18fca4a365e54f61075a5c435d7b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Dermatology

1. O. Levy
2. Bruce S. McEwen
3. A. Danese
4. Shimon Sakaguchi
5. A. Ascherio
6. Eric Wu
7. Hsin-jung Wu
8. K. Munger

In Immunology

1. Hsin-jung Wu
2. Eric Wu
3. Bruce S. McEwen
4. A. Danese
5. O. Levy
6. Richard J. Johnson
7. Y. Lee
8. Shimon Sakaguchi

In Physiology

1. A. Danese
2. O. Levy
3. D. van Sinderen
4. Richard J. Johnson
5. Curtis Huttenhower
6. Bruce S. McEwen
7. Dirk Gevers
8. Shimon Sakaguchi

Citations in the corpus

• Type 1 diabetes: etiology, immunology, and therapeutic strategies. (2011, background): “Making matters complex, however, is the finding that under certain experimental conditions CVB can actually protect from disease (435), supporting the “hygiene hypothesis” (27).”
• Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self (2005, background): “Furthermore, it is well documented that the incidence of autoimmune and other inflammatory diseases, including inflammatory bowel disease and allergy, has increased recently in developed countrie”
• Environmental risk factors for multiple sclerosis. Part I: The role of infection (2007, background): “In fact, observations in animal models of autoimmune diseases suggest that some infections enhance whereas others may contribute to prevent autoimmune diseases.(27,35) Thus, one is left with the task of identifying which infections are important and which are not.”
• Innate immunity of the newborn: basic mechanisms and clinical correlates (2007, result): “, diminishing T H 2-cell polarization and/or enhancing T H 1-cell polarization and thereby potentially reducing allergy and atopy, in accord with the hygiene hypothesis”
• Health, wealth, and air pollution: advancing theory and methods. (2003, background): “In 12 European countries, the prevalence of asthma and diabetes was higher in countries with lower gross national product (Bach 2002).”
• Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters (2015, background): “The incidence of multiple sclerosis (MS), an inflammatory disease of the central nervous system, is increasing in developed countries [1,2].”
• The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota (2017, background): “increases the likelihood of developing atopic disorders (410).”
• IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly. (2005, background): “Infections (specifically through endotoxins) are potent inducers of IL-12 and INF-γ, which are cytokines that stimulate Th1-mediated immunity, and also decrease the production of Th2 inflammatory cytokines, such as IL-4, IL-5, and IL-1”
• Environmental biodiversity, human microbiota, and allergy are interrelated (2012, background): “At the same time, an increasing fraction of the urban population will suffer from chronic inflammatory disorders (2, 3), of which allergic (4) and autoimmune diseases are prime examples.”