Expression of a Functionally Active gp91phox-Containing Neutrophil-Type NAD(P)H Oxidase in Smooth Muscle Cells From Human Resistance Arteries: Regulation by Angiotensin II
By Rhian M. Touyz, Xin Chen, F. Tabet, Guoying Yao, G. He, M. Quinn, P. Pagano, E. Schiffrin. Circulation Research, 2002
616 citations recorded by the source corpus.
Subfields: Immunology, Physiology
View Paper: https://www.semanticscholar.org/paper/125f96f6a7f7160eea2281edd4cf67c625bbd25c
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In Immunology
- Rhian M. Touyz
- E. Schiffrin
- S. Dikalov
- K. Griendling
- B. Lassègue
- J. Lambeth
- R. Clempus
- David I. Brown
In Physiology
Citations in the corpus
- Crosstalk between mitochondria and NADPH oxidases (2011, background): “Nox2, previously known as gp91phox, is present in endothelial and phagocytic cells [88–91].”
- Nox proteins in signal transduction (2009, positive): “DAG and Ca2+ released by IP3 activate protein kinase C (PKC), which phosphorylates p47phox [91,107].”
- Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. (2007, background): “Nox2 accounts for significant ROS generation in vascular smooth muscle in resistance arteries [45] and in endothelium [42,76].”
- Vascular NAD(P)H oxidases: specific features, expression, and regulation. (2003, methodology): “Intracellular hydrogen peroxide is also frequently visualized using fluorescent dyes such as dichlorofluorescein (25, 151, 193, 200, 231).”
- Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. (2004, background): “Nox2 is also expressed in cardiomyocytes, fibroblasts, and vascular smooth muscle of human resistance arteries (14, 126, 153).”
- Reactive oxygen species in vascular biology: implications in hypertension (2004, positive): “…active in all layers of the vessel wall: in the endothelium (Muzaffar et al. 2003), the media (Berry et al. 2000; Touyz et al. 2002a), the adventitia (Rey and Pagano 2002), and in cultured VSMCs, fibroblasts, and endothelial cells (Griendling et al. 1994; Seshiah et al. 2002; Touyz et al. 2002a).”
- Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets (2011, background): “One study has also reported that NOX2 oxidase is expressed in VSMCs in human small gluteal arterie”
- Endothelial dysfunction. (2004, background): “Ang II infusion induces endothelial dysfunction in rats (64–66), increases ROS by stimulating NAD(P)H oxidase (35,67), and promotes vascular inflammation (68).”