A local Wnt-3a signal is required for development of the mammalian hippocampus.

By Scott M. K. Lee, S. Tole, E. Grove, Andrew P. McMahon. Development, 2000

657 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/121b51aeaa15b242e35863bf9df4668359c1408f

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Citations in the corpus

• Dynamic Patterned Expression of Orphan Nuclear Receptor Genes RORα and RORβ in Developing Mouse Forebrain (2003, background): “A similar genetic approach to express DTA in a limited cell population has been used to selectively kill subtypes of spinal neurons in mice [Lee et al., 2000; Yang et al., 2001].”
• Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. (2001, background): “Comparable expression patterns in wild-type and β-catenin mutant embryos were also observed with other markers, i.e. Crabp1(Maden et al., 1992) and the most anteriorly expressed member of the Hox gene family, Hoxa2(Gendron-Maguire et al., 1993; Rijli et al., 1993; not shown), indicating that at…”
• Signalling in neural development: WNTS in the vertebrate nervous system: from patterning to neuronal connectivity (2005, background): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=30144">WNT8B , along with FZ receptors and WNT antagonists, are expressed in the area that surrounds the cortical hem or fimbria, a structure that is crucial for the formation of the hippocampu”
• The Wnt signaling pathway in development and disease. (2004, background): “…(Aulehla et al. 2003; defects, deficiency in neural crest Similar to LEF1/TCF1 Galceran et al. 1999, derivatives, reduction in dorsolateral 2000; Ikeya et al. 1997; neural precursors in the neural tube Lee et al. 2000; (with Wnt1 KO) Yoshikawa et al. 1997) Loss of hippocampus Somitogenesis defects”
• β-catenin is critical for dendritic morphogenesis (2003, unknown): “, while loss-of-function mutations in individual Wnts cause deletions or malformations of distinct brain region”
• Area patterning of the mammalian cortex. (2007, background): “The two major dorsal telencephalic patterning centers that have been most directly implicated in area patterning are the commissural plate (CoP), which expresses several members of the fibroblast growth factor family (Fgfs), and the cortical hem, which expresses bone morphogenetic proteins (Bmps) an”
• Prox1 Is Required for Granule Cell Maturation and Intermediate Progenitor Maintenance During Brain Neurogenesis (2010, background): “Reduced numbers of Notch1+, Ngn2+, and NeuroD1+ cells were also observed by ISH in the mutant DG (Figure 1J,L,N); however, we found no obvious alterations in the expression of Wnt3a in the FNE (Figure S2A,B) [24], or lef1 in the migratory stream (MS) (Figure S2C,D) [25].”
• Wnt signaling and stem cell control (2008, background): “mice exhibit underdevelopment of the hippocampus due to lack of proliferation (Lee et al. 2000).”
• Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh (2009, background): “Sox2 ablation causes early regional loss of Shh and Wnt3a The defective hippocampal development in Sox2 -deleted mice qualitatively mimics that described for mutations of other transcription factors that are part of the Wnt signaling pathway ( Lef1 ) or of Wnt3a itsel”
• Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis (2009, unknown): “Among several Wnt proteins (Wnt3a, Wnt2a, Wnt5a, Wnt7a and Wnt8b”
• Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. (2008, background): “The in vivo development of the cortical hem and choroid plexus requires Wnt and BMP signals ( Lee et al., 2000; Hebert et al., 2003a).”
• Directed differentiation of telencephalic precursors from embryonic stem cells (2005, background): “Recent studies have shown that Wnt genes (expressed in the dorsal pallium) positively control pallial telencephalic specification in vivo”
• Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells (2014, methodology): “After 20 days, the mature EBs were treated with Wnt3a, a WNT protein previously shown to be important for the maintenance of hippocampal progenitors and their differentiation into DG granule neurons (Lee et al., 2000; Machon et al., 2007; Kuwabara et al., 2009; Wexler et al., 2009; Karalay et al., 2”