Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development.

By V. Brault, R. Moore, Stefanie Kutsch, M. Ishibashi, D. Rowitch, Andy McMahon, L. Sommer, O. Boussadia, R. Kemler. Development, 2001

1,130 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/d74e8b407e4b9f9e649141eb499fab53f175dc0e

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Tissue origins and interactions in the mammalian skull vault. (2002, background): “The recent report that Wnt1-Cre conditional inactivation of b-catenin gene function results in a phenotype lacking neural crest derivatives (Brault et al., 2001) appears at first sight to conflict with our observations, since both frontal and parietal bones fail to form in these mice.”
Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. (2009, background): “We were not able to establish critical roles for b-catenin in OLP postnatal myelination owing to 92% postnatal lethality of Olig2-cre X b-catenin(fl/fl) animals (Brault et al. 2001), and we failed to detect precocious myelination in brain or spinal cord at P1 (Supplemental Fig.”
E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer (2009, background): “Canonical WNT signaling emerged also as a potent regulator of various additional developmental processes, contributing to hair follicle morphogenesis, thymocyte and neural delevopment, as well as angiogenesis or adipogenesis [67–72].”
Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors (2006, unknown): “, 2001), -cateninc/c (Brault et al., 2001), Catnbloxex3/loxex3 (Harada et al.”
Regulation of osteoblast differentiation by transcription factors (2006, background): “Further, conditional deletion of b-catenin gene in Wnt1-Cre transgenic mice, in which Cre is expressed in neural crest cell precursors, results in loss of cranial bones derived from neural crest cells [Brault et al., 2001].”
Sequential roles of Hedgehog and Wnt signaling in osteoblast development (2004, background): “Consistent with the crucial role of β-catenin in osteogenesis, a previous study showed that removal of β-catenin from the cranial neural crest cells by Wnt1-Cre resulted in agenesis of most craniofacial bones (Brault et al., 2001).”
Maternal β-catenin and E-cadherin in mouse development (2004, methodology): “…embryo development The floxed β-catenin allele we used in this study has been used to delineate the role of β-catenin and the WNT pathway in development of the brain, neural crest and embryonic endoderm (Brault et al., 2001; Hari et al., 2002; Lickert et al., 2002; Machon et al., 2003).”