Interleukin-17 promotes angiogenesis and tumor growth.

By M. Numasaki, J. Fukushi, M. Ono, S. Narula, P. Zavodny, T. Kudo, P. Robbins, H. Tahara, Michael Lotze. Blood, 2003

875 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/112bb20e20bee322ba6acab08cfc01fa44c18be5

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In Immunology

1. D. Pardoll
2. M. Karin
3. Arlene H. Sharpe
4. C. Dong
5. Yeonseok Chung
6. Xuexian O. Yang
7. V. Kuchroo
8. Hua Yu

In Molecular Biology

1. J. Kundu
2. Aviv Regev
3. M. Karin
4. D. Pardoll
5. Hua Yu
6. Y. Surh
7. N. Restifo
8. Nir Hacohen

In Oncology

1. D. Pardoll
2. M. Karin
3. Hua Yu
4. Arlene H. Sharpe
5. Y. Surh
6. J. Kundu
7. N. Restifo
8. C. Dong

Citations in the corpus

• Th17 cells promote cytotoxic T cell activation in tumor immunity (2009, background): “IL-17A overexpression in tumor cell lines promotes angiogenesis and tumor growth when the tumors are implanted in immunodeficient mice, therefore suggesting a protumor activity (Numasaki et al., 2003).”
• Spatially organized multicellular immune hubs in human colorectal cancer (2021, background): “IL-17 has been shown to promote angiogenesis and tumor expansion in murinemodels (Charles et al., 2009; Chung et al., 2013; Numasaki et al., 2003), including through CAF activation and recruitment of granulocytes that can support tumor growth (Charles et al.”
• STATs in cancer inflammation and immunity: a leading role for STAT3 (2009, neutral): “However, IL-17 can both promote and inhibit tumorigenesi”
• Functional specialization of interleukin-17 family members. (2011, background): “Transplantation of IL-17A-overexpressing tumor cells into immunodeficient mice induced angiogenesis through induction of vascular endothelial growth factor (VEGF) expression, resulting in enhanced tumor growth (Numasaki et al., 2003).”
• A cytokine-mediated link between innate immunity, inflammation, and cancer. (2007, positive): “Similarly, IL-17 overexpression in fibrosarcoma cell lines enhances their tumorigenic growth in C57BL/6 mice (79).”
• Inflammation: gearing the journey to cancer. (2008, background): “For example, IL-17overexpressing human cervical cancer [106], fibrosarcoma [107] and human non-small cell lung cancer [108] showed higher oncogenic growth in vivo.”
• IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway (2009, background): “, 2008), it remains controversial whether IL-17 promotes or inhibits cancer progression (Numasaki et al., 2003; Numasaki et al., 2005; Muranski et al., 2008; Nam et al., 2008; Kryczek et al., 2009; Xiao et al., 2009; Zhang et al., 2009).”
• Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice (2016, background): “In addition, IL-17 plays a prominent role by increasing the angiogenic activity (6) via certain indirect mechanisms, such as (i) induction of IL-17–responsive cells to secrete proinflammatory cytokines, e.”