Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases

By D. Frank, A. S. St. Amand, R. Feldman, E. Boedeker, N. Harpaz, N. Pace. Proceedings of the National Academy of Sciences of the United States of America, 2007

4,462 citations recorded by the source corpus.

Subfields: Epidemiology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/10bd4a09ee0a167faf4a1f092e5d9c079eacefae

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Citations in the corpus

Antioxidant Properties of Probiotic Bacteria (2017, background): “It is reported that the Bacilli class of the Firmicutes and Actinobacteria is rich in the small intestine, whereas the Bacteroidetes and Lachnospiraceae families of the Firmicutes were more prevalent in the colon [116].”
Enteric Dysbiosis Associated with a Mouse Model of Alcoholic Liver Disease (2010, background): “One of these functions is the secretion of antimicrobial effector molecules as part of the mucosal innate immune system.(31) As we have reported, Reg3g is a secreted c-type lectin with potent bactericidal activity that is expressed in intestinal epithelial and Paneth cells, with highest levels found”
Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system (2017, background): “4 Cell Metabolism 26, July 5, 2017 of SCFA-producing microbial species in the gut, and dietary changes that promote production of SCFAs by the microbiome can ameliorate symptoms (Frank et al., 2007; Kanauchi et al., 2002; Machiels et al., 2014; Sokol et al., 2009).”
High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease (2011, background): “In contrast, Enterobacteriaceae were detected in the paired biopsy samples from 5 out of the 6 CD patients included in the study and accounted for a ten-fold increase in proportion of the total CD microbiota compared to the other 1.00E+06 1.00E+07 1.00E+08 1.00E+09 Non-IBD Controls CD Inflamed CD No”
Metal Oxide Nanoparticles Induce Minimal Phenotypic Changes in a Model Colon Gut Microbiota (2015, neutral): “…of the gut microbiota is so prominent in human health that researchers have found links between gut microbes and numerous diseases (Ba¨ckhed et al. , 2004; Ley et al. , 2005, 2006; Manichanh et al. , 2006; Frank et al. , 2007, 2011; Lepage et al. , 2011; Mondot et al. , 2011; Hsiao et al. , 2013).”
Ecological Role of Lactobacilli in the Gastrointestinal Tract: Implications for Fundamental and Biomedical Research (2008, methodology): “The sequences are obtained from DNA extracted from gut samples, using PCR in combination with primers that are conserved for large groups of microbes (4, 22, 26).”
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. (2016, positive): “More specifically, butyrate seems to be related to a protective role based on a significant decrease in the number of butyrate-producing bacteria in the colon of patients with ulcerative colitis and colon cancer (Frank et al., 2007; Wang et al., 2012) and an amelioration of experimental colitis (AOM”
The first 1000 cultured species of the human gastrointestinal microbiota (2014, background): “, 2008), but even when present, these bacteria constitute an extremely minor fraction, as indicated by the fact that only one of over 15 000 SSU rRNA gene sequences in the study of the microbiota of inflammatory bowel disease patients and controls originated from a Gemmatimonadetes bacterium (Frank ”
Intestinal barrier and gut microbiota: Shaping our immune responses throughout life (2017, background): “prausnitzii with Crohn s Disease (CD) and others inflammatory bowel diseases (IBDs).(24,25) SCFAs are inhibitors of histone deacetylases (HDACs) that tend to promote a tolero-”
The role of microbiome in central nervous system disorders (2013, positive): “015 titers against indigenous bacteria, a drastic change of gut microbiome, and favorable response to antibiotic intervention (Frank et al., 2007; Macpherson et al., 1996).”
Microbiomes in light of traits: A phylogenetic perspective (2015, background): “Thus, the composition of gut microbiomes from inflammatory bowel disease (IBD, including ulcerative colitis and Crohn’s disease) patients differs from that of healthy microbiomes at the class and phylum levels (81).”
New evidences on the altered gut microbiota in autism spectrum disorders (2017, background): “Several inflammatory conditions have been related to an increase in the Firmicutes/Bacteroidetes ratio such as inflammatory bowel diseases (IBDs) [34] and obesity [35].”