HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells.

By M. Betts, M. Nason, S. M. West, S. De Rosa, S. Migueles, J. Abraham, M. Lederman, J. Benito, P. Goepfert, M. Connors and 2 more. Blood, 2006

1,974 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases, Virology

View Paper: https://www.semanticscholar.org/paper/10b5c013c81fd8c5293bae980b81d80b55d735bc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Mario Roederer
2. F. Sallusto
3. Steven G. Deeks
4. E. Wherry
5. Daniel C. Douek
6. R. Koup
7. V. Appay
8. D. Sauce

In Infectious Diseases

1. Daniel C. Douek
2. Mario Roederer
3. R. Koup
4. V. Appay
5. D. Sauce
6. Steven G. Deeks
7. E. Wherry

In Virology

1. Daniel C. Douek
2. Steven G. Deeks
3. Mario Roederer
4. R. Koup
5. V. Appay
6. D. Sauce
7. F. Sallusto

Citations in the corpus

• Phenotype and function of human T lymphocyte subsets: Consensus and issues (2008, background): “Specifically, when comparing the HIV-specific T cell response among HIVinfected, clinically defined progressors or long-term nonprogressors, there is a significantly better quality of the CD8 T cell response from the latter group (46,47).”
• Immune activation and inflammation in HIV‐1 infection: causes and consequences (2008, background): “For instance, long-term nonprogression may be established through the action of certain populations of HIV-specific CD8+ T cells that display polyfunctional characteristics [69] and/or proliferative capacity [70], and are able to maintain low viral load in infected patients.”
• T cell exhaustion (2011, background): “For example, it is rare to find HIV-specific CD8 + T cells that do not make IFN-γ, although defects in polyfunctionality and cytotoxicity can occu”
• Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control (2008, methodology): “Therefore, unlike cells treated with anti-CD3, antiCD28, and IL-2, PMA+Io-treated cells mediated significantly greater cytotoxicity of peptide-pulsed targets compared with D6 Gag cells, in a manner that overlapped with activity of cells from LTNPs (Figures 7C–7E).”
• Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. (2008, background): “For example, controllers have much stronger polyfunctional HIV-specific CD8+ T cell responses than chronically HIV-infected patients maintaining antiretroviral treatment–mediated viral suppression [5], and they are enriched for protective class I HLA haplotypes associated with delayed disease progre”
• Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major (2007, background): “Indeed, it has recently been shown that CD8 + T cells from HIV-infected individuals with better control of infection have an increased frequency of multifunctional cells compared with those individuals with progressive diseas”
• PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection (2006, background): “Under chronic antigen stimulation HIV-specifi c CD8+ T cells, which lack CD4+ T cell help, express an impaired ability to produce cytokines (termed “exhaustion”) (5).”
• Emerging Concepts in the Immunopathogenesis of AIDS (2009, background): “The efficacy of ART in 474 Douek · Roederer · Koup A nn u.”
• Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 (2020, positive): “This phenotype has been associated with stem-like properties (Betts et al., 2006; Blom et al., 2013; Demkowicz et al., 1996; Fuertes Marraco et al., 2015; Precopio et al., 2007).”