Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
By P. Darrah, Dipti T. Patel, P. D. Luca, Ross W. B. Lindsay, Dylan F. Davey, Barbara Flynn, S. Hoff, P. Andersen, S. Reed, S. Morris and 2 more. Nature Medicine, 2007
1,408 citations recorded by the source corpus.
Subfields: Hematology, Infectious Diseases, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/bb0377eb92164366276db01354d52fff58913e12
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In Infectious Diseases
Citations in the corpus
- Leishmaniasis: complexity at the host–pathogen interface (2011, background): “Recent studies suggest that the most protective CD4 + T cells are those that are multifunctional, capable of producing not only IFNγ, but also IL-2 and TN”
- Differentiation of Effector CD4 T Cell Populations (2010, neutral): “For example, the IFN-γ+TNFα+IL-2+ multifunctional Th1 cells, but not the single cytokine producers, are likely to be the long-lasting memory cells (285).”
- Phenotype and function of human T lymphocyte subsets: Consensus and issues (2008, background): “major infection demonstrates that the quality of the T cell response is predictive of control following challenge (69).”
- SPICE: Exploration and Analysis of Post-Cytometric Complex Multivariate Datasets (2011, background): “As an example, protection afforded by a vaccine against Leishmania major was correlated with the magnitude of only those CD4 cells that simultaneously produced three cytokines—a fraction of the total CD4 response (11).”
- Emerging Concepts in the Immunopathogenesis of AIDS (2009, neutral): “Third, each polyfunctional T cell produces as much as tenfold the amount of each cytokine produced by a monofunctional T cell, bringing to bear a far larger effector response directly at the effector site (76, 79, 80).”
- Immunity to malaria: more questions than answers (2008, background): “Protection is associated with the development of T helper type 1 cells producing TNF or IL-2 and IFN-γ, not IFN-γ alon”