Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19
By T. Sekine, André Perez-Potti, Olga Rivera-Ballesteros, K. Strålin, J. Gorin, Annika Olsson, S. Llewellyn-Lacey, Habiba Kamal, G. Bogdanovic, S. Muschiol and 19 more. bioRxiv, 2020
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SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. We systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in a large cohort of unexposed individuals as well as exposed family members and individuals with acute or convalescent COVID-19. Acute phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative family members and individuals with a history of asymptomatic or mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits robust memory T cell responses akin to those observed in the context of successful vaccines, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19 also in seronegative individuals.
Subfields: Infectious Diseases, Neurology
View Paper: https://www.semanticscholar.org/paper/4bbfc05db4964aeb96d937a7272786bee1127f29
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Citations in the corpus
- Adaptive immunity to SARS-CoV-2 and COVID-19 (2021, background): “The presence of cross-reactive memory T cells capable of recognizing SARS-CoV-2 in a fraction of the population is intriguing, because it opens the possibility of some degree of pre-existing immunity in the population (Sette and Crotty, 2020).”
- Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 (2020, background): “[23], a particularly high frequency of spike protein-specific CD4+ T cell responses was observed in patients”