Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells
By J. Christensen, Irving L. Weissman. Proceedings of the National Academy of Sciences of the United States of America, 2001
855 citations recorded by the source corpus.
Subfields: Hematology, Immunology
View Paper: https://www.semanticscholar.org/paper/10a718ce35acf76bc51b22e2f293eeae383d210c
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Hematology
- Irving L. Weissman
- Derrick J. Rossi
- R. Majeti
- Frank Rosenbauer
- A. Trumpp
- David Bryder
- Daniel G. Tenen
- Anne Wilson
In Immunology
- Florent Ginhoux
- Irving L. Weissman
- R. Majeti
- Miriam Merad
- Derrick J. Rossi
- Daniel G. Tenen
- Frank Rosenbauer
- E. Stanley
Citations in the corpus
- Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells. (2013, positive): “…multipotent self-renewing HSCs, mainly characterized by a CD150 + CD34 À/low Flt3 À c-Kit + Sca-1 + lineage À (CD150 + CD34 À Flt3 À KSL) phenotype (Christensen and Weissman, 2001; Kiel et al., 2005; Morita et al., 2010; Morrison and Weissman, 1994; Osawa et al., 1996), initially give rise to…”
- Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. (2007, background): “The minor c-kit+Lin Sca1+ (KLS) compartment can be resolved into functionally distinct subsets based on differential expression of CD34 and flk2 (Adolfsson et al., 2001; Christensen and Weissman, 2001; Yang et al., 2005).”
- Transcription factors in myeloid development: balancing differentiation with transformation (2007, background): “Long-term HSCs give rise to short-term HSCs (LIN − IL-7Rα − SCA1 + KIT + FLT3 low Thy1 low CD34 + ), which retain the ability for multilineage differentiation potential, but have decreased self-renewal potentia”
- The origin and development of nonlymphoid tissue CD103+ DCs (2009, background): “One population expresses langerin, CD103 (Cepek et al., 1994), and low levels of CD11b but lacks several monocyte/macrophage markers including F4/80 (Austyn and Gordon, 1981), SIRP(van Beek et al., 2005), and CX3CR1 (Jung et al., 2000; CD103+ DC; Fig.1, A and B).”
- Long-term propagation of distinct hematopoietic differentiation programs in vivo. (2007, background): “The persistence of such a significant contribution to myelopoiesis by these CD45lin Rho SP cells clearly distinguishes them functionally from STRCs, which have been defined in the literature by an inability to produce detectable GM progeny beyond 6–12 weeks (Morrison and Weissman, 1994; Adolfsson et”
- c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. (2004, background): “As it has recently been shown that functional LT-HSC activity is exclusively contained within the Flk2/Flt3Rneg (CD135neg) subset of the KLS population (c-Kit+linnegSca1+Flk2neg (KLSF) (Adolfsson et al. 2001; Christensen and Weissman 2001), the proportion of KLS cells expressing this receptor was de”
- Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. (2007, background): “MPP lie immediately downstream of HSC within the hematopoietic hierarchy and have been identified in mouse bone marrow on the basis of their distinct surface immunophenotype (Christensen and Weissman, 2001; Morrison et al., 1997; Morrison and Weissman, 1994).”