Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling

By A. Gavin, K. Hoebe, B. Duong, T. Ota, Christopher Martin, B. Beutler, D. Nemazee. Science, 2006

626 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/108826c79830210d5701d8faa9a1b6568f37d46f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Annick Mayor
2. J. Tschopp
3. Fabio Martinon
4. G. Núñez
5. R. Flavell
6. Shizuo Akira

In Immunology

1. J. Tschopp
2. G. Núñez
3. Fabio Martinon
4. Annick Mayor
5. L. Franchi
6. H. Hammad
7. Virginie Petrilli
8. F. Sutterwala

Citations in the corpus

• Function of Nod‐like receptors in microbial recognition and host defense (2009, background): “bodies induced by Alum is independent of TLRs, IL-1R, and IL-18R signaling (204), a major challenge for future studies will be the elucidation of the pathway(s) through which Alum induces an adaptive immune response and adjuvant activity.”
• The inflammasomes: guardians of the body. (2009, background): “Unfortunately, TLR agonists may be too toxic to be used in human vaccines; moreover, immune responses to an antigen can also occur in the absence of TLR signaling (227).”
• Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants (2008, methodology): “d, Lung draining (hilar) lymph nodes were collected from WT and Nalp3-deficient mice primed and challenged as in a and pooled within each group for restimulation; cells were restimulated in vitro with (1) or without (2) 200mg ml(21) ovalbumin and mitomycin-C-treated splenocytes for 48 h.”
• Mechanisms of Action of Adjuvants (2013, background): “…response activated Licensed vaccines Reference Alum No depot effect ↑ Ab responses Many human vaccines (e.g., DTap, Hib, Hepatitis A, Hepatitis B) Gavin et al. (2006), Franchi and Nùñez (2008), Kool et al. (2008a), McKee et al. (2009), Hutchison et al. (2012) NLRP3 activation in vivo?”
• Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome (2008, background): “Mice lacking TLR signaling components still mount a robust Ab responses if alum is given as an adjuvant (5).”