Increased Number of Islet-Associated Macrophages in Type 2 Diabetes

By J. Ehses, A. Perren, E. Eppler, P. Ribaux, J. Pospisilik, R. Maor-Cahn, Xavier Guéripel, H. Ellingsgaard, Mårten K. J. Schneider, G. Biollaz and 4 more. Diabetes, 2007

776 citations recorded by the source corpus.

Subfields: Epidemiology, Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/1061ed9d09b0582c2728270e6d622f7b215266cb

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Citations in the corpus

Aging and aging-related diseases: from molecular mechanisms to interventions and treatments (2022, background): “These macrophages are prone to polarize toward the proinflammatory (M1) type.(280,281) Insulin resistance is a major factor for the pathogenesis of T2DM, which accelerates β-cell senescence.”
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells (2011, neutral): “(p M p er 3 0 is le ts ) * e Ctrl Ctrl Ctrl ex (9-39) Ctrl ex (9-39) 30 1.”
Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020, background): “Whereas TNF-α may inhibit β‐cell function indirectly, IL‐1β has been identified as a direct key player in β‐cell damage (183-189), although IL-1β inhibition with canakinumab did not reduce the incidence of diabetes (190).”
Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids (2018, background): “However, currently, it is known that there are other tissues involved in meta-inflammation, such as the liver [54], pancreas [55], hypothalamus [56,57], and skeletal muscle [58].”
Molecular mechanisms of cancer development in obesity (2011, background): “Interestingly, there is evidence that obesity increases macrophage infiltration in other tissues such as pancreatic islet”
The cellular and signaling networks linking the immune system and metabolism in disease (2012, background): “Increased numbers of macrophages have been observed in the pancreatic islets of HFD-fed rodents as well as in islets from individuals with type 2 diabete”
Type 2 diabetes as an inflammatory disease (2011, background): “Tissue inflammation has also been detected in the islets of patients with T2D, along with increased levels of cytokines and chemokine”
The role of inflammation in insulitis and β-cell loss in type 1 diabetes (2009, background): “Patients with type 2 diabetes mellitus might also undergo a mild increase in their number of islet-associated macrophages”