Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3.

By G. A. McQuibban, J. Gong, E. Tam, C. McCulloch, I. Clark‐Lewis, Christopher M. Overall. Science, 2000

822 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology and Allergy, Oncology

View Paper: https://www.semanticscholar.org/paper/1009f9aa6033cabbeef6084eed4bcb08ed4e1347

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Citations in the corpus

Matrix metalloproteinases as modulators of inflammation. (2008, methodology): “CC chemokine ligand 7 (CCL7/MCP3) is cleaved by MMP2 in which removal of the four (N)terminal amino acids from the active CCL7 chemokine molecule converts it to a truncated form that can still bind to its CC chemokine receptor, but cannot activate it, thus functioning as a receptor antagonist [4].”
Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. (2002, methodology): “Figure 2 shows that MCP-1 is cleaved at Ala4-Ile5, designated MCP-1(5-76); by MMP-1; to a lesser extent (20% of total by densitometric analysis) by MMP-3; and to a very minor extent (5% of total) by MMP-8.”
New functions for the matrix metalloproteinases in cancer progression (2002, background): “cgi?l=6354">CCL7 (also known as monocyte chemoattractant protein-3; MCP-3), and the cleaved fragment not only is inactivated but also becomes an antagonist to the receptor”
Strategies for MMP inhibition in cancer: innovations for the post-trial era (2002, background): “By destroying chemokine gradients that are laid down in the peritumour stroma to attract immune cells, tumour-derived MMPs assist in circumventing the host antitumour defence syste”
Chemokines in cutaneous wound healing (2001, background): “Whether metalloproteinases down-regulate inflammation in wound healing via cleavage of chemokines, which then act as antagonists as has recently been shown for gelatinase A and MCP-3 (CCL7) in vitro [30], remains to be elucidated in vivo.”
Targeting proteases: successes, failures and future prospects (2006, methodology): “The yeast two-hybrid system, which is widely used in the identification of physiological ligands of proteins, was shown to work also in the protease field and led to the identification of monocyte chemoattractant protein 3 ( MCP3 ) as an MMP2 substrate using the haemopexin domain of MMP2 as a bai”
Matrix metalloproteinases. (2010, background): “MMPs can also modulate antitumour immune reactions by efficiently cleaving several chemokines or regulating their mobilization [143-145].”
Metalloproteinases in biology and pathology of the nervous system (2001, background): “The cleaved MCP3 binds to several chemokine receptors, acting as an antagonist 99 .”
Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors (2005, background): “…cleavage of growth factors has been implicated in activation, in the alteration of biological properties, and in growth factor degradation (Fuentes-Prior et al., 2000; Junttila et al., 2000; McQuibban et al., 2000, 2002; Bergsten et al., 2001; Borrell-Pages et al., 2003; Nanba et al., 2003).”