Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
By Takeshi Fujiwara, Madhavi Bandi, M. Nitta, E. Ivanova, R. Bronson, D. Pellman. Nature, 2005
1,084 citations recorded by the source corpus.
Subfields: Cancer Research, Cell Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/10005fc29d840df9ba81952f67d30cd590f8f8ae
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cell Biology
Citations in the corpus
- Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. (2006, background): “Alternatively, it is possible that cells with stem-like properties reemerge from some established cell line populations, through epigenetic reprogramming and/or selection of a subpopulation of cells with genomic instability as seen in our 0308 serum-cultured cells (Fujiwara et al., 2005; Kondo and R”
- Aurora B-mediated abscission checkpoint protects against tetraploidization. (2009, positive): “, 2007), as recently demonstrated in a mouse model (Fujiwara et al., 2005).”
- Roles of Aurora Kinases in Mitosis and Tumorigenesis (2007, background): “Aurora Kinases in Tumor Suppressor Gene Dysfunction and Cell Viability Aurora-A interacts with several tumor suppressor gene products, including p53 (92, 95, 96), BRCA1 (97), NM23-H1 (98), and Chfr (99), and it might be a powerful way to promote cell viability and tumorigenesis.”
- DNA breaks and chromosome pulverization from errors in mitosis (2012, background): “Intriguingly, two animal models where whole-chromosome segregation errors result in robust tumour development also display extensive structural alterations in chromosome”
- The evolutionary consequences of polyploidy. (2007, background): “Polyploids may also exhibit higher rates of segregation errors, especially when centrosomes are duplicated, causing an aneuploid cascade, which has been shown to facilitate tumorigenesis (Fujiwara et al., 2005; Storchova and Pellman, 2004).”
- Absolute quantification of somatic DNA alterations in human cancer (2012, neutral): “MPD (205) GIST (36) Lung adeno (543) Esophageal squamous (32) Lung squamous (46) Breast cancer (134) Liposarcoma (93) Other sarcoma (66) Esophageal adeno (69) Prostate cancer (61) Ovarian cancer (90) MFH (36) ALL (235) Medulloblastoma (96) Colorectal cancer (125) HCC (108) Cell lines (364) Neuroblas”
- Boveri revisited: Chromosomal instability, aneuploidy and tumorigenesis (2009, background): “The most direct evidence for this came from the observation that tetraploid p53 −/− mouse cells initiate tumour formation when transplanted into immunocompromised mice, whereas isogenic diploid cells do no”