Boveri revisited: Chromosomal instability, aneuploidy and tumorigenesis

By A. Holland, D. Cleveland. Nature reviews. Molecular cell biology, 2009

881 citations recorded by the source corpus.

The mitotic checkpoint is a major cell cycle control mechanism that guards against chromosome missegregation and the subsequent production of aneuploid daughter cells. Most cancer cells are aneuploid and frequently missegregate chromosomes during mitosis. Indeed, aneuploidy is a common characteristic of tumours, and, for over 100 years, it has been proposed to drive tumour progression. However, recent evidence has revealed that although aneuploidy can increase the potential for cellular transformation, it also acts to antagonize tumorigenesis in certain genetic contexts. A clearer understanding of the tumour suppressive function of aneuploidy might reveal new avenues for anticancer therapy.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/4d4b217b65f23a5ecbde74af9e431a725803975e

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Citations in the corpus

Allele-specific copy number analysis of tumors (2010, background): “Complicating factors are that tumor cells are often aneuploid (9, 10) and that tumor samples contain multiple populations of both tumor and nontumor cells (11, 12).”
Mitotic catastrophe: a mechanism for avoiding genomic instability (2011, background): “, or via polyploid intermediates that undergo sequential steps of illegitimate (and imperfect) polyploidization and depolyploidizatio”
Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy (2017, background): “M any human solid tumors are characterized by aneuploidy, the presence of an abnormal number of chromosomes (1).”
Absolute quantification of somatic DNA alterations in human cancer (2012, background): “We note that this model represents a departure from the idea that tetraploidization is an initiating event 47,13,26,48,49 .”