Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice

By S. Dillon, C. Sprecher, A. Hammond, J. Bilsborough, Maryland Rosenfeld-Franklin, Scott R. Presnell, H. Haugen, M. Maurer, B. Harder, J. Johnston and 20 more. Nature Immunology, 2004

967 citations recorded by the source corpus.

Subfields: Dermatology, Immunology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/0fd68eb7854cb509868f90dc365aac8ddfad61f8

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Citations in the corpus

Atopic dermatitis: a disease of altered skin barrier and immune dysregulation (2011, background): “Sonkoly E, et al. IL-31: a new link between T cells and pruritus in atopic skin inflamma- tion.”
New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions (2005, background): “Nevertheless, the recent identification of IL-31, which utilizes a heterodimeric signalling complex composed of a gp130-like molecule (GLMR; also known as IL-31Rα) and the oncostatin-M recepto”
Interleukin‐6 biology is coordinated by membrane‐bound and soluble receptors: role in inflammation and cancer (2006, background): “protein to form an IL-31-specific receptor complex [3].”
A mechanism for the initiation of allergen-induced T helper type 2 responses (2008, background): “Basophils secrete T H 2-promoting cytokines Papain strongly induced the expression of transcripts encoding IL-2, IL-4, IL-13, IL-31, TSLP and the chemokine CCL1, which have all been associated with T H 2 cell differentiation and recruitment, in purified basophil”
Interleukin-6 Family Cytokines. (2018, background): “2), which binds to a receptor complex formed by the OSM-R and the IL31RA (Dillon et al. 2004).”
The neurobiology of itch (2006, background): “However, the discovery that IL-31 induces pruritic dermatitis in mic”
Th2 Cytokines and Atopic Dermatitis (2011, background): “Injection of IL-31 directly into the skin resulted in increased recruitment of inflammatory cells into the skin, suggesting a role for IL-31 in chemotaxis [123].”
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases. (2016, background): “IL31mRNA is upregulated in the lungs after antigen challenge in a mouse model of airway inflammation.(13) In addition, serum IL-31 levels are increased in a subset of patients with mastocytosis and correlate with disease severity.”