Endotoxin tolerance: new mechanisms, molecules and clinical significance.

By Subhra K. Biswas, E. López-Collazo. Trends in immunology, 2009

1,324 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology

View Paper: https://www.semanticscholar.org/paper/0f9feae585a39a2c6537b6c6ec33b6f534608eca

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. A. Mantovani
2. G. Natoli
3. T. Lawrence
4. S. Ghosh

In Immunology

1. A. Mantovani
2. Subhra K. Biswas
3. M. Locati
4. P. Italiani
5. D. Boraschi
6. G. Curtale
7. G. Natoli
8. A. Thomson

Citations in the corpus

• Applications of nanotechnology for immunology (2013, background): “Endotoxin tolerance is a mechanism by which immunosuppression occurs in the continued presence of LPS 118 .”
• Antigen-presenting cell function in the tolerogenic liver environment (2010, background): “The refractory behaviour of freshly isolated liver mDCs to LPS stimulation is known as 'endotoxin tolerance”
• Transcriptional regulation of macrophage polarization: enabling diversity with identity (2011, background): “This altered state of responsiveness to secondary stimulation is commonly referred to as endotoxin tolerance and results in a global and sustained switch of the gene expression programme from a pro-inflammatory M1 signature to an M2-like anti-inflammatory phenotyp”
• From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation (2014, background): “endotoxin tolerance, an altered state of responsiveness to secondary stimulation with LPS, resulting in a global and sustained switch of the gene expression program from an inflammatory M1 signature to an anti-inflammatory phenotype (199); obesity-induced insulin resistance or type 2 diabetes, and a”
• Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm (2010, background): “Under appropriate conditions, exposure to LPS results in hyporesponsiveness to subsequent challenge at the macrophage and organism level (referred to as 'endotoxin tolerance'”
• Microglial M1/M2 polarization and metabolic states (2016, background): “LPS-induced tolerant macrophages express a transcriptional profile similar to M2 polarization with Il10, Arg1, Ccl17 and Ccl22 rather than a diminished M1 response, suggestive of a reorientation of function (Biswas and Lopez-Collazo, 2009; Porta et al., 2009).”
• Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans. (2016, neutral): “…of immunosuppression was originally described in sepsis, but is thought to underlie multiple other physiological contexts of innate immune unresponsiveness, such as the immune protective effect conferred by microbial exposure suggested by the hygiene hypothesis (Biswas and Lopez-Collazo, 2009).”