Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1
By L. Birder, Y. Nakamura, S. Kiss, M. Nealen, S. Barrick, A. Kanai, Edward C Y Wang, Giovanni W. Ruiz, W. C. Groat, G. Apodaca and 2 more. Nature Neuroscience, 2002
723 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Sensory Systems, Urology
View Paper: https://www.semanticscholar.org/paper/0f796267d4c2f29141c5cfcbd99e4ecb4ef9e131
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In Cellular and Molecular Neuroscience
In Sensory Systems
Citations in the corpus
- An introduction to TRP channels. (2006, background): “In contrast to SOCE and most TRP channels, La and Gd (10--100 μM) alone also activate and, in the presence of Gq/11 agonists, potentiate receptormediated activation of TRPC4, TRPC5, and heteromers containing them (75, 81, 82) and [Ca]i-activated currents through TRPM4 are transiently stimulated by L”
- Mechanisms of sensory transduction in the skin (2007, background): “TRPV1 is dispensable for cutaneous mechanosensation; however, this channel is required for normal stretch-evoked reflexes in the bladde”
- TRP channels as cellular sensors (2003, background): “TRPV1 also participates in mechanically evoked purinergic signalling by the bladder urotheliu”
- The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept (2007, background): “— although they do exhibit increased urine voiding or 'spotting' behaviou”
- Handbook of ion channels (2015, background): “the bladder (140), the enteric nervous system, the innervation”
- Transient receptor potential cation channels in disease. (2007, background): “These findings indicate that TRPV1 participates in normal bladder function and is essential for normal, mechanically evoked purinergic signaling from the urothelium to sensory afferent fibers (47, 48).”