Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1

By L. F. Michael, Zhidan Wu, R. Cheatham, P. Puigserver, G. Adelmant, J. J. Lehman, D. Kelly, B. Spiegelman. Proceedings of the National Academy of Sciences of the United States of America, 2001

687 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/0f36c16bc4e2da4f4244293b94ab8939f249b5be

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Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. (2004, background): “…several of the PGC-1 partners serve functions outside of the mitochondrion such as HNF-4 and FOX-01 (gluconeogenesis; Rhee et al. 2003; Puigserver et al. 2003) and MEF-2 (glucose transport; Michael et al. 2001), others are linked to the mitochondrial biogenic transcriptional regulatory program.”
Exercise induces transient transcriptional activation of the PGC‐1α gene in human skeletal muscle (2003, background): “In C2C12 myotubes, forced expression of PGC-1a causes a dramatic increase in the expression of NRF-1, NRF-2a and mtTFA, as well as GLUT4 and several nuclear genes that encode for components of the respiratory chain (Wu et al. 1999; Michael et al. 2001).”
Metabolic control through the PGC-1 family of transcription coactivators. (2005, background): “Ectopic expression of PGC-1α in myotubes stimulates GLUT4 expression and mitochondrial oxidative metabolism (Michael et al., 2001).”
Regulation of energy metabolism by long-chain fatty acids. (2014, background): “4, PGC1a acts as a coactivator of key transcription factors that mediate adaptation of skeletal muscle to endurance exercise such as PPARd, NRF, ERRa and MEF2.”
Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. (2003, background): “Fourth, recent work has shown that genes for mitochondrial proteins and the primary glucose transporter in muscle, GLUT4, are regulated by common signals, including elevations in cytosolic calcium (29,30) and the transcriptional coactivator PGC-1 (peroxisome proliferator–activated receptor [PPAR]- c”
Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC‐1 (2002, background): “Adenovirus-mediated expression of PGC-1 in cultured muscle cells results in a large increase in GLUT4, providing evidence that PGC-1 can control GLUT4 gene expression (31).”
PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. (2006, background): “In addition, several non-NR PGC-1 partners have been identified, including myocyte enhancer factor-2 (MEF-2) (30), forkhead box O1 (FOXO1) (31), SREBP1 (27), and Sry-related HMG box-9 (Sox9) (32).”
A practical model of low‐volume high‐intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms (2010, background): “The regulation of skeletal muscle glycogen content by PGC-1α is not completely understood, but may involve PGC-1α mediated up-regulation of GLUT4 (Michael et al. 2001) and/or modulation of enzymes involved in glycogen synthesis and degradation (Wende et al. 2007).”
Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. (2001, background): “in vivo (Michael et al., 2001), PGC-1 is almost Figure 3.”