Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

By D. Stoffers, T. Kieffer, M. Hussain, D. J. Drucker, S. Bonner-Weir, J. Habener, J. Egan. Diabetes, 2000

607 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Genetics, Surgery

View Paper: https://www.semanticscholar.org/paper/0eb60022af7fbc1c4c39db84e89b92a05f35cf1c

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In Endocrinology, Diabetes and Metabolism

1. Josephine M. Egan
2. Wook Kim
3. D. J. Drucker
4. Jens J. Holst
5. J. Gromada
6. Ralph DeFronzo
7. M. Nauck
8. J. Meier

In Surgery

1. Josephine M. Egan
2. Wook Kim
3. Jens J. Holst
4. D. J. Drucker
5. J. Gromada
6. Ralph DeFronzo
7. M. Nauck
8. J. Meier

Citations in the corpus

• Glucagon-like peptide-1 receptor is involved in learning and neuroprotection (2003, background): “Indeed, GLP-1 exerts effects on glucose-dependent insulin secretion, insulin biosynthesis, gastrointestinal motility, islet b-cell neogenesis, energy homeostasis and food intak”
• In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. (2003, background): “Partial pancreatectomy (49), chronic glucose infusion (7, 50), and glucagon-like peptide-1 and its analog exendin-4 (3) stimulate IPF-1 and endocrine hormone gene expression in pancreatic ducts and exocrine compartments.”
• Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. (2004, background): “Not only does it stimulate -cell proliferation (70, 84), it also enhances the differentiation of new -cells from progenitor cells in the pancreatic duct epithelium (86).”
• The Role of Incretins in Glucose Homeostasis and Diabetes Treatment (2008, background): “Other experiments performed on transgenic mice also point to the necessity of PDX-1 for the full complement of GIP-expressing cells (Boyer et al., 2006), illustrating the importance of PDX-1 not only for its well known effects on pancreatic and -cell development, but also for K-cell development.”
• The role of FoxO in the regulation of metabolism (2008, background): “GLP-1 signaling, which can converge on the insulin receptor pathway, decreases nuclear FoxO1 and increases Pdx-1 expression (Buteau et al., 1999; Wang et al., 1999; Stoffers et al., 2000).”