BAX and BAK Regulation of Endoplasmic Reticulum Ca2+: A Control Point for Apoptosis
By L. Scorrano, Scott A Oakes, J. Opferman, E. Cheng, M. Sorcinelli, T. Pozzan, S. Korsmeyer. Science, 2003
1,488 citations recorded by the source corpus.
Subfields: Epidemiology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/0e7184a489d17352d26f0656ee9a885b2f9badb4
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In Epidemiology
- Guido Kroemer
- R. Kaufman
- J. Malhotra
- Douglas R. Green
- John Calvin Reed
- Beth Levine
- D. Ron
- Jerry M. Adams
In Molecular Biology
- Guido Kroemer
- Douglas R. Green
- R. Kaufman
- Jerry M. Adams
- D. Ron
- J. Malhotra
- J. Chipuk
- John Calvin Reed
Citations in the corpus
- Ischemia/Reperfusion (2016, neutral): “modifying the extent of I/R injury (701).”
- Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis (2008, background): “Indeed, it is becoming increasingly appreciated that ER-mitochondrial calcium signaling is crucial in several models of apoptosis (Demaurex and Distelhorst, 2003; Orrenius et al., 2003; Rizzuto et al., 2003; Scorrano et al., 2003).”
- OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. (2006, positive): “Images were stored for subsequent analysis, background subtraction and normalization which was performed exactly as described in ( Scorrano et al., 2003 ).”
- A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death (2012, positive): “For cells lacking BAX/BAK, it has been suggested that their reduced steady-state levels of ER-Ca 2 þ (Scorrano et al , 2003) might play an important role in ecto-CRT induction (Tufi et al , 2008; Panaretakis et al , 2009).”
- Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario (2006, background): “occur in the absence of BAX and BAK (although BAX and BAK may function to control Ca2þ release from ER) suggesting mPT pore involvement.(28) However, under physiological”
- Ways of dying: multiple pathways to apoptosis. (2003, background): “, etoposide) may require that Bax/Bak act both in the ER to discharge Ca ions and in mitochondria to permeabilize its outer membrane (Scorrano et al. 2003; Zong et al. 2003).”