Identification of renox, an NAD(P)H oxidase in kidney.

By M. Geiszt, J. Kopp, P. Várnai, Thomas L. Leto. Proceedings of the National Academy of Sciences of the United States of America, 2000

870 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/0e5c851f5df1bbe9604286504966184f530213eb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. J. Lambeth
2. B. Lassègue
3. R. Clempus
4. S. Klebanoff
5. Y. Bae
6. Rhian M. Touyz
7. E. Schiffrin
8. K. Griendling

In Molecular Biology

1. Y. Bae
2. J. Lambeth
3. S. Klebanoff
4. P. Oliver
5. R. Clempus
6. B. Lassègue

In Pediatrics, Perinatology and Child Health

1. J. Lambeth

Citations in the corpus

• Upsides and Downsides of Reactive Oxygen Species for Cancer: The Roles of Reactive Oxygen Species in Tumorigenesis, Prevention, and Therapy (2012, neutral): “Another major source of ROS, in the form of superoxide or H 2 O 2 , is NOX and its dual oxidase relatives, which are localized to various cellular membranes (26, 96, 174, 288, 291).”
• Vascular NAD(P)H oxidases: specific features, expression, and regulation. (2003, background): “However, cell proliferation was decreased by nox4 in NIH 3T3 cells (56, 173) and increased in melanoma cells (26), suggesting that its effects depend very much on the cellular context.”
• Myeloperoxidase: friend and foe (2005, background): “quent studies, this group and others [115–119] have identified”
• Oxidant Mechanisms in Renal Injury and Disease (2016, neutral): “Of the NAPDH oxidase isoforms in the kidney, NOX4 is expressed the highest (90) producing large amounts of hydrogen peroxide constitutively (296).”
• Nox proteins in signal transduction (2009, neutral): “Nox4, originally Renox, was discovered in the kidney [14,15], and soon afterwards was described in osteoclasts [16].”
• Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. (2007, background): “Nox4 is expressed in high levels in kidney [99,100], while other Nox1, Nox2 and Nox regulatory subunits are expressed at lower but quantitatively significant levels [101,102], making Nox enzymes attractive candidates for the origin of renal ROS including the relatively high levels of H2O2 seen in ur”