Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder.

By D. Cotter, D. Mackay, Gursharan Chana, C. Beasley, S. Landau, I. Everall. Cerebral Cortex, 2002

612 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Biophysics, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/0d7ae1d8d35373c0ffcfabf3f9dd598616b2aba4

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Citations in the corpus

Cellular changes in the postmortem hippocampus in major depression. (2004, background): “In contrast to the increase in cell density noted in hippocampus, studies by Ongur et al (1998), Rajkowska et al (1999), Cotter et al (2001, 2002), and Bowley et al (2002) report a decrease in the density or number of glia in various regions of frontolimbic cortex and amygdala in depression.”
Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression (2008, background): “…or left is to left and/or glia-to-neuron ratios additionally were found in MDD subjects versus controls in the pregenual ACC (pgACC [BA24]) (Cotter et al. 2001a), the dorsal anterolateral PFC (BA9) (Cotter et al. 2002; Uranova et al. 2004) and the amygdala (Bowley et al. 2002; Hamidi et al. 2004).”
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms (2008, background): “One of the most consistent neuropathological findings in MDD is a reduction in the number of glia (Ongur et al, 1998; Rajkowska et al, 1999; Cotter et al, 2001, 2002; Uranova et al, 2004).”
The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission (2011, background): “For example, PFC regions of post-mortem brain samples from individuals suffering from mood disorders showed markedly reduced glial cell numbers and densit”
Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. (2007, neutral): “4) [4-43] Episode duration, mean (SD) [range], mo 140 (130) [15-480] Total illness duration, mean (SD) [range], y 18.”
Neurocircuitry of Mood Disorders (2010, background): “In several reports, the deficits in glia in the cerebral cortex depended upon laminar analysis with the greatest effects in layers III, V, and VI (Cotter et al, 2001a, 2002; Rajkowska et al, 1999, 2001; Uranova et al, 2004; Vostrikov et al, 2007).”