The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

By M. Popoli, Zhen Yan, Bruce S. McEwen, G. Sanacora. Nature Reviews Neuroscience, 2011

1,345 citations recorded by the source corpus.

Mounting evidence suggests that acute and chronic stress, especially the stress-induced release of glucocorticoids, induces changes in glutamate neurotransmission in the prefrontal cortex and the hippocampus, thereby influencing some aspects of cognitive processing. In addition, dysfunction of glutamatergic neurotransmission is increasingly considered to be a core feature of stress-related mental illnesses. Recent studies have shed light on the mechanisms by which stress and glucocorticoids affect glutamate transmission, including effects on glutamate release, glutamate receptors and glutamate clearance and metabolism. This new understanding provides insights into normal brain functioning, as well as the pathophysiology and potential new treatments of stress-related neuropsychiatric disorders.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/2ef2b6f262a83e7a04f915e4382d49f7251949c4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

1. R. Duman
2. G. Sanacora
3. Matthew N Hill
4. John H. Krystal
5. M. Morena
6. Sachin Patel
7. J. Bains
8. Bruce S. McEwen

In Biological Psychiatry

1. R. Duman
2. G. Sanacora
3. Matthew N Hill
4. John H. Krystal
5. Bruce S. McEwen
6. M. Morena
7. Sachin Patel
8. J. Bains

In Cellular and Molecular Neuroscience

1. Bruce S. McEwen
2. R. Duman
3. G. Sanacora
4. John H. Krystal
5. E. Nestler
6. L. Monteggia
7. Peter J. Gianaros
8. H. Schmidt

Citations in the corpus

• Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments (2019, background): “The effects of stress can also be mimicked by long-term administration of adrenal glucocorticoids indicating a role for the HPA axis (Popoli et al., 2011).”
• Neurobiological and Systemic Effects of Chronic Stress (2017, background): “Glucocorticoids produce effects in the brain both genomically and non-genomically via multiple sites and pathways, and they have biphasic effects in which the timing and the level of glucocorticoid response (GR) expression are critical.(25,26) Glucocorticoid actions via the genome involve both direc”
• Neurobiological Interactions Between Stress and the Endocannabinoid System (2016, background): “Recently, the effects of stress on synaptic transmission and plasticity have become a growing area of research (reviewed in (Joels et al, 2009; Popoli et al, 2011; Senst and Bains, 2014; Bains et al, 2015).”