DUSP11-mediated control of 5′-triphosphate RNA regulates RIG-I sensitivity

By Joon-Ho Choi, J. Burke, K. Szymanik, Upasana Nepal, Anna M. Battenhouse, Justin T Lau, A. Stark, V. Lam, C. S. Sullivan. 2020

28 citations recorded by the source corpus.

In this study, Choi et al. set out to elucidate the physiological role of RNA triphosphatase dual-specificity phosphatase 11 (DUSP11) in the innate immune response. Using in vivo and in vitro experiments, the authors describe the importance of controlling 5′-triphosphate RNA levels to prevent aberrant RIG-I signaling and demonstrate DUSP11 as a key effector of this mechanism.

Subfields: Immunology, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Wenshuai Wang
2. Anna Marie Pyle

In Molecular Biology

1. Wenshuai Wang
2. C. S. Sullivan
3. Anna Marie Pyle

Citations in the corpus

• The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands (2022, background): “Abundant cellular p1dsRNAs also include mRNA degradation and triphosphorylase intermediates (Braun et al., 2012; Choi et al., 2020; Choi and Sullivan, 2021; Jonas and Izaurralde, 2013; Nagarajan et al., 2013; van Dijk et al., 2002).”
• DUSP11 and triphosphate RNA balance during virus infection (2021, background): “Consistent with these aberrant RNAs having biological impact, DUSP11-deficient mice display a signature of enhanced interferon signaling and show greater sensitivity to exogenous 5’-PPP RNA [17].”