Role of Histone H3 Lysine 27 Methylation in X Inactivation

By Kathrin Plath, Jia Fang, Susanna Mlynarczyk-Evans, R. Cao, Kathleen A. Worringer, Hengbin Wang, Cecile C. de la Cruz, A. Otte, B. Panning, Yi Zhang. Science, 2003

1,276 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0d0ad77be700b611bac7ac608bdaff171bb4cdf9

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Citations in the corpus

Transcriptional regulation by Polycomb group proteins (2013, background): “; and from the Novo Nordisk Foundation, the Danish Cancer Society and the Danish Council for Strategic Research (12-110503) to K.”
Non-coding RNAs in human disease (2011, background): “lncRNAs are essential in many physiological processes, such as X-chromosome inactivation in mammals, in which the X-inactivation specific transcript ( XIST ) lncRNA (17 kb) recruits the polycomb complex to silence the X chromosome from which it is transcribe”
Systematic discovery of Xist RNA binding proteins (2015, background): “Furthermore, in the A-repeat deletion Xist mutant, PRC2 and H3K27me3 are still recruited to the Xist-coated chromosome (da Rocha et al., 2014; Plath et al., 2003).”
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. (2006, background): “For instance, H3-K27Me3 is associated with an inactive X chromosome (Fong et al., 2002; Kelly et al., 2002; Reuben and Lin, 2002; Plath et al., 2003; Rougeulle et al., 2004), but H3-K27Me1 is”
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation (2008, background): “(such as the SW48 cells studied here), the two mechanisms of gene silencing will also interact, as they do on the inactive-X chromosom”
The Xist lncRNA exploits three-dimensional genome architecture to spread across the X-chromosome (2013, background): “Xist initiates X-chromosome inactivation (XCI) by spreading in cis across the future inactive X chromosome (20, 21), recruiting polycomb repressive complex 2 (PRC2) (14, 22, 23), and forming a transcriptionally silent nuclear compartment (24, 25) enriched for repressive chromatin modifications inclu”
Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation. (2008, background): “All these data point to the fact that the antisense RNA targeting to the chromatin in cis is carried out in an organized manner and is synonymous to what has been proposed for Xist.”
Systematic allelic analysis defines the interplay of key pathways in X chromosome inactivation (2018, background): “In addition to the aforementioned factors, Xist RNA recruits the Polycomb repressive complexes PRC1 and PRC2 that catalyse the histone modi ﬁ cations H2AK119ub and H3K27me3, respectively 26 – 28 .”
The profile of repeat‐associated histone lysine methylation states in the mouse epigenome (2005, background): “By contrast, H3-K27 trimethylation is enriched at the inactive X chromosome (Plath et al, 2003; Silva et al, 2003; Kohlmaier et al, 2004).”