Ras signalling on the endoplasmic reticulum and the Golgi

By V. Chiu, T. Bivona, A. Hach, J. Sajous, Joseph Silletti, Heidi H. Wiener, Ronald L. Johnson, A. Cox, M. Philips. Nature Cell Biology, 2002

642 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/0d088774d87280b34da5f75ef72bcaa18b0e4902

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1. John Hancock

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Citations in the corpus

• Ras proteins: different signals from different locations (2003, background): “When cells expressing wild-type H-ras are stimulated with EGF, GFP–Raf-RBD is initially recruited to the plasma membrane and then progressively to the Golg”
• Development of an optimized backbone of FRET biosensors for kinases and GTPases (2011, background): “This increase in FRET/CFP was probably caused by the bystander FRET (i.e., local increase in the concentration of the FRET biosensors at the plasma membrane could result in the stochastic intermolecular FRET; Supplemental Figure S6; Chiu et al., 2002).”
• Ras oncogenes: split personalities (2008, neutral): “Moreover, although activated H-Ras is associated with both the Golgi apparatus and the endoplasmic reticulum (ER), only the ER-associated form can activate RAF1–ERK signallin”
• Integrating signals from RTKs to ERK/MAPK (2007, background): “More recently, studies utilizing new imaging technologies, such as fluorescence resonance energy transfer, have revealed that activated Ras proteins can be detected on various intracellular membranes, including the Golgi and endoplasmic reticulum as well as endosomes (Burke et al., 2001; Chiu et al.”
• Signalling ballet in space and time (2010, neutral): “The second paradigm illustrates that the specificity of ERK substrate phosphorylation may be determined by the localization of upstream signal”
• Targeting RAS signalling pathways in cancer therapy (2003, background): “Several other non-receptor proteins can also become tyrosine phosphorylated and act as anchors for GRB2 interaction, and there are several other GEFs for RAS that are controlled quite differentl”