Ras oncogenes: split personalities

By A. Karnoub, R. Weinberg. Nature reviews. Molecular cell biology, 2008

1,469 citations recorded by the source corpus.

Extensive research on the Ras proteins and their functions in cell physiology over the past 30 years has led to numerous insights that have revealed the involvement of Ras not only in tumorigenesis but also in many developmental disorders. Despite great strides in our understanding of the molecular and cellular mechanisms of action of the Ras proteins, the expanding roster of their downstream effectors and the complexity of the signalling cascades that they regulate indicate that much remains to be learnt.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/00b012877be786e1ef156cf75d113cd2648ba56d

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Citations in the corpus

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases (2011, background): “Regulation of both Ras and Raf is crucial for the proper maintenance of cell proliferation, as activating mutations in these genes lead to oncogenesis (181).”
KRAS: feeding pancreatic cancer proliferation (2014, neutral): “The recognition over thirty years ago that mutationally activated RAS genes are present in human cancer cells led to intense efforts to understand the Ras protein structure, biochemistry, and biology; studies that arguably shaped our understanding of the molecular biology of cancer today [1,2].”
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? (2010, neutral): “uk/genetics/CGP/cosmic/">COSMIC database ; Further information”
RAS oncogenes: weaving a tumorigenic web (2011, background): “This question has been predominantly instigated by the well-recognized non-random distribution pattern of activated isoforms of RAS among the range of cancer type”
The Roles of Autophagy in Cancer (2018, background): “the development of some deadly cancers, including lung, colon, and pancreatic [82,83,84,85].”
Dynamic modularity in protein interaction networks predicts breast cancer outcome (2009, background): “In contrast, partners that employ RAS as an effector (that is, Insulin receptor adaptor protein, IRS1 (ref”
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (2009, positive): “The Ras family of small GTPases are frequently mutated in human cancers (reviewed in Karnoub and Weinberg, 2008 ).”
Dragging ras back in the ring. (2014, background): “Harvey sarcoma virus, Kirsten sarcoma virus, and Rasheed sarcoma virus contain Ras genes (so named for their role in forming rat sarcomas; reviewed in Barbacid, 1987; Karnoub and Weinberg, 2008).”
Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. (2013, neutral): “Worst grade of 5 14 (5) 16 (6) 30 (6) 19 (7) 10 (4) 29 (5)”
Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies (2023, background): “2,3 Although many RAS inhibitors have been isolated and studied, the development of drugs targeting RAS is limited by a lack of well-de ﬁ ned druggable nooks and cavities on the RAS surface.”