Integrating signals from RTKs to ERK/MAPK

By M. McKay, DK Morrison. Oncogene, 2007

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Cadherin switching (2008, background): “How does cadherin switching influence cell behavior? Growth factor receptors regulate many aspects of cell behavior, including cell motility and invasion (McKay and Morrison, 2007).”
The Ras-ERK and PI3K-mTOR Pathways: Cross-talk and Compensation (2011, background): “MP1 (MEK1 scaffolding protein), which scaffolds MEK and ERK at late endosomes and is required for sustained ERK activity, also scaffolds the Rag GTPases to the lysosome [1, 6, 37].”
Phosphatase‐mediated crosstalk between MAPK signaling pathways in the regulation of cell survival (2008, background): “Most of the signals activating the ERK pathway are initiated through receptor-mediated activation of the small G-protein, Ras (10) (Fig.”
Targeting the Mitogen-Activated Protein Kinase RAS-RAF Signaling Pathway in Cancer Therapy (2012, background): “Accordingly, Ras communicates external cellular signals to the nucleus, and its altered activation leads to inappropriate cellular activities including enhanced cell growth, differentiation, survival and ultimately to cancer [1,8,9].”
Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. (2012, background): “The biochemistry, biology, and regulation of Ras-dependent ERKs activation have been extensively reviewed (192, 229).”