Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?

By E. Passegué, Catriona H. M. Jamieson, L. Ailles, Irving L. Weissman. Proceedings of the National Academy of Sciences of the United States of America, 2003

782 citations recorded by the source corpus.

Subfields: Hematology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/0cd1886d7ab9d4c49b1faedfe67d70a1a8c7fa43

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In Hematology

1. humAn cArcinogens
2. Iarc Monographs
3. peRsonAl hAbIts
4. M. Clarke
5. Irving L. Weissman

Citations in the corpus

• iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “Data to support a cancer stem cell concept for solid tumours have been reported (Al-Hajj et al., 2003; Hemmati et al., 2003; Passegué et al., 2003; Singh et al., 2003; Serakinci et al., 2004).”
• Cancer stem cells: models and concepts. (2007, background): “In many cases, a detailed understanding of the true hierarchy of human leukemic cell populations is still hampered by the many uncertainties regarding the hierarchy of the early stages of normal human hematopoiesis (11).”
• Tissue repair and stem cell renewal in carcinogenesis (2004, background): “The possibility cannot be excluded, however, that cancer stem cells might be derived from more committed progenitors by genetic or epigenetic changes that confer self-renewal abilit”
• Malignant astrocytic glioma: genetics, biology, and paths to treatment. (2007, background): “The identification of the “cell of origin” remains an area of active research for both hematological malignancies (Passegue et al. 2003) and solid tumors (Al-Hajj et al. 2003; Singh et al. 2004; Sanai et al. 2005; Taylor et al. 2005; Patrawala et al. 2006; Li et al. 2007; O’Brien et al. 2007;…”
• Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. (2007, background): “CD133 is expressed by normal tissue-resident as well as hematopoietic stem cells (Peichev et al., 2000; Uchida et al., 2000; Yin et al., 1997).”
• Isolation and Characterization of Tumorigenic, Stem-like Neural Precursors from Human Glioblastoma (2004, neutral): “otherwise silent/latent stem cell properties (5).”
• Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region (2007, background): “dtd" [ ]> Acute myelogenous leukemia (AML) is the most common adult leukemia, characterized by the clonal expansion of immature myeloblasts initiating from rare leukemic stem (LS) cell”