Long-range chromatin regulatory interactions in vivo

By David R F Carter, L. Chakalova, Cameron S. Osborne, Yan-feng Dai, Peter Fraser. Nature Genetics, 2002

691 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/0c34caf1d295c03b1138b5e600538d2c9a6ba97e

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In Molecular Biology

Citations in the corpus

Quantitative analysis of chromosome conformation capture assays (3C-qPCR) (2007, background): “The recent development of the “Tagging and recovery of associated proteins&rdquo”
CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. (2007, positive): “Upon erythroid differentiation, the LCR forms stable contacts with the active (cid:1) -globin genes and strongly up-regulates their transcription rate (Carter et al. 2002; Tolhuis et al. 2002).”
Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome (2005, background): “In fact, chromatin looping was recently detected in the β-globin locu”
Long-range control of gene expression: emerging mechanisms and disruption in disease. (2005, background): “Chromatin fragments tagged with biotin are then purified on streptavidinagarose columns, and the relative enrichment of a specific DNA fragment (detected by PCR) indicates that the tagged sequence was in the vicinity of the nascent mRNA and, by extrapolation, of the promoter (Carter et al. 2002).”
Genomic maps of lincRNA occupancy reveal principles of RNA-chromatin interactions (2011, background): “Prior studies mapping RNA occupancy at chromatin have revealed substantial insights (Carter et al., 2002; Nagano et al., 2008), but only at single gene locus at a time.”
Cooperativity in long-range gene regulation by the λ CI repressor (2004, background): “…or repression of promoter activity by proteins bound to enhancer or silencer elements located several kilobases away from the promoter has been recognized for many years; however, a precise molecular understanding of any of these multiprotein interactions is still lacking (see Carter et al. 2002).”
Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops (2004, background): “Direct physical interactions and looping have been shown for the β-globin locus, where a remote enhancer interacts with the globin gen”
CTCF mediates long-range chromatin looping and local histone modification in the β-globin locus (2006, neutral): “Upon erythroid differentiation, the LCR forms stable contacts with the active -globin genes and strongly up-regulates their transcription rate (Carter et al. 2002; Tolhuis et al. 2002).”
Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements. (2006, methodology): “Large-scale mapping of chromatin interactions Genome Research 1305 www.genome.org RNA-TRAP showed that the expressed globin gene interacted most strongly with HS2 (Carter et al. 2002).”
Interchromosomal interactions and olfactory receptor choice. (2006, methodology): “Washes and antibody staining were performed using standard techniques (Carter et al., 2002).”
Controlling long range genomic interactions at a native locus by targeted tethering of a looping factor (2012, positive): “Fundamental insights into these issues arose from studies of the mammalian b-globin locus, which is among the first gene clusters at which long-range chromosomal interactions between a powerful distal enhancer, the locus control region (LCR), and the target b-globin promoters were described (Carter ”