ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor.

By D. Cosman, J. Müllberg, Claire L. Sutherland, W. Chin, R. Armitage, W. Fanslow, M. Kubin, N. Chalupny. Immunity, 2001

1,376 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/0c077f7c557c6bff5928a641f828f484edb5f503

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. D. Raulet
2. E. Latz

In Immunology

1. D. Raulet
2. M. Smyth
3. L. Lanier
4. I. Waldhauer
5. A. Steinle
6. É. Vivier
7. S. Ugolini
8. J. Trapani

Citations in the corpus

• NK cells and cancer immunosurveillance (2008, background): “All ULBP have a MHC class I-like a1a2 platform domain, but lack an a3 domain, and are anchored in the plasma membrane either by a GPI structure (ULBP1-3, RAET1L) or by a transmembrane domain (ULBP4 and RAET1G) (Cosman et al., 2001; Radaev et al., 2001; Bahram et al., 2005).”
• Targeting natural killer cells and natural killer T cells in cancer (2012, background): “NKG2D interacts with self molecules that are selectively upregulated on stressed cells, such as tumour cell”
• A fresh look at tumor immunosurveillance and immunotherapy (2001, background): “Subse-quently, genes encoding human ULBP have been found in the chromosomal region syntenic to genes encoding mouse Rae-1 and their products bind human NKG2”
• Natural killer cells, viruses and cancer (2001, background): “More recently, another family of ligands for human NKG2D, designated as UL16-BINDING PROTEINS (ULBPs), was reporte”
• Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity (2001, background): “Several distinct cell-surface ligands that are related to class I major histocompatibility complex molecules have been identifie”
• Roles of the NKG2D immunoreceptor and its ligands (2003, background): “A distinct approach identified three related human proteins that bind to the UL16 protein of human cytomegalovirus (HCMV) and are encoded by a gene family that is homologous to the Rae1/H60/Mult1 gene famil”
• Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2 (2003, background): “At least four gene products interfere with major histocompatibility complex class I antigen presentation (16, 58), and two CMV-encoded proteins interact with HLA-E, which leads to suppression of NK responses and protection from NK-mediated lysis (12, 54, 57).”
• Immunobiology of Human Cytomegalovirus: from Bench to Bedside (2009, neutral): “preventing the activation of NK cells (50).”