Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast

By Zu-Wen Sun, C. D. Allis. Nature, 2002

1,175 citations recorded by the source corpus.

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Elongation by RNA polymerase II: the short and long of it. (2004, background): “Components of PAF are also required for Rad6-mediated histone H2B monoubiquitination, a histone modification shown to be a prerequisite for H3-K4 and H3-K79 methylation (Briggs et al. 2002; Dover et al. 2002; Sun and Allis 2002; Ng et al. 2003a; Wood et al. 2003).”
The diverse functions of histone lysine methylation (2005, background): “However, evidence for a certain level of ‘cross-talk’ between different covalent histone modifications does exist 28–30 , although the generality of these observations are unclear.”
Ubiquitin and ubiquitin-like proteins as multifunctional signals (2005, background): “cerevisiae , the ubiquitin-conjugating enzyme Rad6 (Ubc2) monoubiquitylates K123 on histone H2B, which, in turn, mediates the methylation of K4 on histone H3 (Ref”
SUMO and ubiquitin in the nucleus: different functions, similar mechanisms? (2004, background): “…monoubiquitination affects the nucleosome came with the demonstration by several groups that monoubiquitination of histone H2B in yeast is required for methylation GENES & DEVELOPMENT 2053 of histone H3 at Lys 4 and Lys 79 (Briggs et al. 2002; Dover et al. 2002; Ng et al. 2002; Sun and Allis 2002).”
Histone acetylation and deacetylation in yeast (2003, positive): “Ubiquitylation at Lys123 of H2B is required for the methylation of Lys4 and Lys79 of histone H3 (Ref”
Acetylation of the p53 DNA-binding domain regulates apoptosis induction. (2006, background): “This type of crosstalk between distinct post-translational modifications occurs on histones (Sun and Allis, 2002) and has been suggested to occur on p53 as well (Sakaguchi et al., 1998).”
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. (2005, positive): “Both Rtf1 and Rad6 are necessary for methylation by Set1 of histone H3 lysine 4 near 5# ends of genes (Ng et al., 2003; Sun and Allis, 2002), and they have more recently been implicated in elongation (Xiao et al., 2005).”
Role of histone H2A ubiquitination in Polycomb silencing (2004, background): “and a ‘cross-talk’ between H2B ubiquitination and histone methylatio”
Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. (2004, methodology): “Alternatively, uH2A may function through a transhistonesard et al., 1999). regulatory pathway, as has been reported for H2B ubiquitylation in S. cerevisiae (Sun and Allis, 2002; Dover et al., 2002; Briggs et al., 2002).”
The role of chromatin during transcription. (2007, background): “One commonly accepted role of H2Bub1 in transcription is to stimulate di-and trimethylation of histone H3K4 (Dehe et al., 2005; Shahbazian et al., 2005; Sun and Allis, 2002).”