Aging of the Innate Immune System
By A. Shaw, Samit R. Joshi, H. Greenwood, A. Panda, J. Lord. Current Opinion in Immunology, 2010
641 citations recorded by the source corpus.
Summary The innate immune system is composed of a network of cells including neutrophils, NK and NKT cells, monocytes/macrophages, and dendritic cells that mediate the earliest interactions with pathogens. Age-associated defects are observed in the activation of all of these cell types, linked to compromised signal transduction pathways including the Toll-like Receptors. However, aging is also characterized by a constitutive pro-inflammatory environment (Inflamm-aging) with persistent low-grade innate immune activation that may augment tissue damage caused by infections in elderly individuals. Thus, immunosenescence in the innate immune system appears to reflect dysregulation, rather than exclusively impaired function.
Subfields: Immunology, Neurology
View Paper: https://www.semanticscholar.org/paper/3dd1c4cfdb994cb9d01d3bedc67e72b73c2b1cd1
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In Immunology
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In Neurology
Citations in the corpus
- Aging, Cellular Senescence, and Cancer (2012, background): “There are also age-related changes in the innate immune system, although they tend to be less striking than the changes in adaptive immunity; moreover, the aged innate immune system is more likely to show a loss of proper regulation than a loss of function (142, 143).”
- Causes, consequences, and reversal of immune system aging. (2013, positive): “Despite the increase in their number, myeloid-biased stem cells are not as robust as their young counterparts (24), which in turn could underlie the numerous age-related deficiencies observed in mature myeloid cells such as neutrophils and macrophages (25, 26).”
- The hallmarks of aging. (2013, background): “For example, hematopoiesis declines with age, resulting in a diminished production of adaptive immune cells—a process termed immunosenescence—and in an increased incidence of anemia and myeloid malignancies (Shaw et al., 2010).”
- A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance and healthspan (2015, background): “…causes a diminished or altered production of adaptive immune cells, a phenomenon known as ‘‘immunosenescence,’’ manifested as a shift in the lymphoid-to-myeloid ratio and elevated incidence of anemia andmyeloidmalignancies (Figures 2O–2S) (Muller-Sieburg et al., 2004; Shaw et al., 2010).”