Faculty Opinions recommendation of A microRNA in a multiple-turnover RNAi enzyme complex.

By W. Filipowicz. 2002

207 citations recorded by the source corpus.

Subfields: Cancer Research, Ecology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0ab391d345095acd61275ec7269ed59eab8aee6c

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Citations in the corpus

Computational identification of Drosophila microRNA genes (2003, background): “Interestingly, perfect or near-perfect target complementarity is associated with mRNA degradation [24-26], similar to the effects of siRNA, whereas imperfect base-pairing is associated with regulation by translational inhibition [6,27].”
The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. (2007, unknown): “Such duplexes are known to mimic the miRNA function (Hutvagner and Zamore 2002).”
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs (2005, unknown): “This observation, together with the documented overlap between the potential activities of siRNAs and metazoan miRNA”
Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. (2004, unknown): “…and also exports the adenovirus VA1 RNA via a minihelix motif (Gwizdek et al. 2003). microRNAs (miRNAs) are widespread among eukaryotes and represent key components of a conserved system of RNAbased gene regulation (Cullen 2002; Hutvagner and Zamore 2002b; Carrington and Ambros 2003; Cerutti 2003).”
MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5′ region (2004, background): “siRNAs will direct RNA cleavage or translational repression ( Hutvagner and Zamore, 2002; Zeng et al, 2002; Doench et al, 2003; Saxena et al, 2003; Zeng et al, 2003).”
A combined computational-experimental approach predicts human microRNA targets. (2004, background): “The manner by which a miRNA or siRNA base pairs with its mRNA target correlates with its function: if the complementarity between a miRNA and its target is extensive, the RNA target is cleaved (Hutvagner and Zamore 2002; Llave et al. 2002; Rhoades et al. 2002; Tang et al. 2003; Xie et al. 2003); if ”
Knocking down barriers: advances in siRNA delivery (2009, unknown): “The activated RISC complex can then move on to destroy additional mRNA targets, which further propagates gene silencing 15 .”
Expanding the MicroRNA Targeting Code: Functional Sites with Centered Pairing (2010, unknown): “Argonaute-catalyzed cleavage of the target strand occurs in the context of extensive base pairing, at the linkage joining the mRNA nucleotides that pair to miRNA positions 10 and 11 (Elbashir et al., 2001b; Hutvagner and Zamore, 2002; Yekta et al., 2004).”
A three-dimensional view of the molecular machinery of RNA interference (2009, unknown): “Slicing requires perfect complementarity between the guide strand and the target around the cleavage sit”