Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host.

By Bo-Yang Huang, Ping-Ying Pan, Qingsheng Li, Alice I Sato, D. Levy, J. Bromberg, C. Divino, Shu-Hsia Chen. Cancer Research, 2006

1,475 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/0a934f1ee6f83906f2b4a1ec25af428665ab656d

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In Immunology

1. D. Gabrilovich
2. A. Mantovani
3. S. Ostrand-Rosenberg
4. A. Sica
5. V. Bronte
6. P. Allavena
7. P. Sinha
8. C. Garlanda

Citations in the corpus

• Subsets of Myeloid-Derived Suppressor Cells in Tumor Bearing Mice (2008, background): “It has been previously reported that CD11b cells expressing MCSF receptor (CD115) or IL-4R (CD124) had potent immunosuppressive activity (22, 23).”
• Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells (2008, background): “MDSC from 4T1 tumor-bearing mice have a consistent phenotype of Gr1 CD11b F4/80 IL4R / Arginase iNOS CD80 , contradicting some studies suggesting that IL-4R is a definitive marker for mouse MDSC (35, 54).”
• Pro-Resolving lipid mediators and Mechanisms in the resolution of acute inflammation (2014, background): “novo development of T-regulatory cells (Treg) (Huang et al., 2006).”
• Myeloid derived suppressor cells promote cross-tolerance in B cell lymphoma by expanding regulatory T cells (2008, background): “previously suggested (24), it is still unclear whether MDSCs increase Treg numbers through the conversion of naive T cells or the expansion of a preexisting antigen-specific Treg population.”
• Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells (2008, methodology): “(66) used a colon carcinoma mouse model (MCA) expressing the influenza hemagglutinin (HA) antigen.”
• Myeloid derived suppressor cells (2013, background): “The induction of Tregs by MDSCs occurs through a direct cell-cell interaction or via production of specific soluble factors, including IL-10 in the presence of TGFβ, or arginase (which is TGFβ independent).(45,46) Animal studies have implicated cytotoxic lymphocyte antigen-4 (CTLA4) expression by MD”
• Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects (2020, background): “Hirata A, Hashimoto H, Shibasaki C, Narumi K, Aoki K. Intratumoral IFN-alpha gene delivery reduces tumor-infiltrating regulatory T cells through the downregulation of tumor CCL17 expression.”
• Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression (2018, positive): “Induction of other immunosuppressive cells MDSCs were shown to be able to induce the de novo generation of FoxP3 Treg cells in vivo through a mechanism that was mediated by interferon (IFN)-γ and IL-10, but was independent of nitric oxide (NO) production.(35) CD14HLA-DR M-MDSCs isolated from patient”