T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin.

By C. Hug, Jin Wang, N. Ahmad, J. Bogan, T. Tsao, H. Lodish. Proceedings of the National Academy of Sciences of the United States of America, 2004

887 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/0a16fe89bc33c0de2e02fe56a8efe70263ed0db6

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Citations in the corpus

Adipocytokines: mediators linking adipose tissue, inflammation and immunity (2006, background): “In addition, T-cadherin , which is expressed by many cells including endothelial cells and smooth muscle cells, seems to function as a receptor for middle-molecular-weight and high-molecular-weight adiponectin, but not for the trimeric (low-molecular-weight) and globular form”
Adiponectin Regulation and Function (2018, positive): “T-cadherin receptor does not have a transmembrane or intracellular domain, but plays a role in binding adiponectin and promoting adiponectin signaling in endothelial and smooth muscle cells, which are the major sites of T-cadherin expression (114).”
Regulation of energy metabolism by long-chain fatty acids. (2014, background): “T-cadherin was identified as a receptor of secreted HMW and hexamer adiponectin, but not of a globular or full-length adiponectin trimer [206].”
Adipose tissue-derived factors: impact on health and disease. (2006, background): “In addition to the adiponectin receptors AdipoR1 and -2, T-cadherin is also a candidate adiponectin receptor (149).”
Involvement of members of the cadherin superfamily in cancer. (2009, background): “CDH13 probably serves as coreceptor with the more classic adiponectin-receptor-1 and -2 for binding hexameric and larger adiponectin forms (Hug et al. 2004).”
Adiponectin and adiponectin receptors. (2005, background): “Lodish’s group reported that T-cadherin was capable of binding adiponectin in C2C12 myoblasts, but not in the liver or hepatocytes (80).”
Adiponectin: mechanistic insights and clinical implications (2012, background): “An additional cell surface molecule with significant affinity for adiponectin, referred to as T-cadherin, has been identified [12].”
Adipocytes as regulators of energy balance and glucose homeostasis (2006, background): “59 ); a second molecule (T-cadherin) without a transmembrane domain has been proposed to act as a co-receptor for the high-molecular-weight form of adiponectin on endothelial and smooth muscle cell”