The Hallmarks of Cancer Review

By D. Hanahan, R. Weinberg. 2000

2,190 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/0a0105f0f69957abc0a6e6f7e085cdf4813b88bd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. D. Hanahan
2. M. Karin
3. A. Mantovani
4. A. Sica
5. P. Allavena
6. J. Pollard
7. F. Colotta
8. F. Greten

Citations in the corpus

• EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. (2008, background): “Prognostic variability and resistance against therapeutic agents in cancer are likely governed by the heterogeneity of activated gene expression patterns and molecular pathways, which may be related to differences in cellular origin ( 2 , 31).”
• Survivin, versatile modulation of cell division and apoptosis in cancer (2003, background): “This is consistent with the general paradigm that deregulated apoptosis inhibition contributes to malignancy by favoring the accumulation of additional ‘cancer traits’ (Hanahan and Weinberg, 2000), codifying more aggressive disease behaviors (Evan and Vousden, 2001).”
• Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell. (2003, background): “Stunning examples include the lysis–lysogeny switch of viruses [1], chemotaxis in bacteria [2], the DNA-division cycle of yeasts [3], segmentation patterns in fruit fly development [4] and signal transduction pathways in mammalian cells [5].”
• Molecular imaging in drug development (2008, background): “Solid tumours are often characterized by having high glucose utilization, tumour cell proliferation, hypoxia with sustained angiogenesis and evasion of apoptosi”
• Cisplatin: mode of cytotoxic action and molecular basis of resistance (2003, background): “Members of the Bcl-2 family are key players in regulating apoptosis (Farrow and Brown, 1996; Hanahan and Weinberg, 2000; Schuler and Green, 2001).”
• Luteolin, a flavonoid with potential for cancer prevention and therapy. (2008, background): “In addition, cancer cells elicit an angiogenic response, evade mechanisms that limit cell proliferation (such as apoptosis and senescence), and elude immune surveillance [67].”
• Mitogen-activated protein kinases in apoptosis regulation (2004, background): “Tumors develop when delicate balance among cell cycle, proliferation, differentiation, and apoptosis is disrupted by genetic and/or environmental cues (Hanahan and Weinberg, 2000).”
• Gene-expression profiles predict survival of patients with lung adenocarcinoma (2002, result): “This result is consistent with the complex molecular architecture of tumors in general, the heterogeneity of lung adenocarcinomas in particular and the multiple mechanisms underlying tumor-cell survival, invasion and metastasi”
• A cytokine-mediated link between innate immunity, inflammation, and cancer. (2007, unknown): “Mechanisms that link inflammation and cancer Cancer is a hyperproliferative disorder that involves morphological cellular transformation, dysregulation of apoptosis, uncontrolled cellular proliferation, invasion, angiogenesis, and metastasis (1).”
• eIF-4E expression and its role in malignancies and metastases (2004, background): “It is well established that defective processes of cellular homeostasis, like functions involved in DNA repair and genomic stability, result in a predisposition toward malignant transformation (Hanahan and Weinberg, 2000).”
• Perturbations of the AKT signaling pathway in human cancer (2005, background): “In such cases, the abundance of a given receptor may enable a tumor cell to become hypersensitive to ambient levels of growth factors (Hanahan and Weinberg, 2000).”
• Myc's broad reach. (2008, background): “Taken together, the expression profiling data indicate that Myc has the capacity to both stimulate cell growth and abrogate cell cycle inhibitors, a powerful combination of functions that, when deregulated, may drive the limitless replicative potential characteristic of nearly all tumors (Hanahan an”
• The Bcl-2 family: roles in cell survival and oncogenesis (2003, background): “This discovery engendered the concept that impaired apoptosis is central to tumour development, a view that is now widely embraced (Cory et al., 1999; Hanahan and Weinberg, 2000; Green and Evan, 2002).”