eIF-4E expression and its role in malignancies and metastases

By A. Benedetti, J. Graff. Oncogene, 2004

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Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. (2005, background): “In addition to Akt, the treatment of NSCLC cells with rapamycin also induced the phosphorylation of eIF4E (p-eIF4E), a molecule downstream of mTOR that is involved in promoting cell survival (8, 14).”